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Genome-wide single-nucleotide polymorphism array-based karyotyping in myelodysplastic syndrome and chronic myelomonocytic leukemia and its impact on treatment outcomes following decitabine treatment

Title
Genome-wide single-nucleotide polymorphism array-based karyotyping in myelodysplastic syndrome and chronic myelomonocytic leukemia and its impact on treatment outcomes following decitabine treatment
Authors
Kim H.-J.Yi J.H.Huh J.Kim S.-H.Kim S.H.Kim K.H.Do Y.R.Mun Y.-C.Kim H.Kim M.K.Kim T.Kim D.D.H.
Ewha Authors
허정원문영철
SCOPUS Author ID
허정원scopus; 문영철scopus
Issue Date
2013
Journal Title
Annals of Hematology
ISSN
0939-5555JCR Link
Citation
vol. 92, no. 4, pp. 459 - 469
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Decitabine is a hypomethylating agent with proven clinical efficacy in myelodysplastic syndrome (MDS). The current study analyzed the role of single nucleotide polymorphism array (SNP-A)-based karyotyping in prediction of clinical outcome in MDS or chronic myelomonocytic leukemia (CMML) patients following decitabine therapy. A total of 61 MDS/CMML patients treated with decitabine were evaluated with Genome-Wide Human SNP 6.0 Array using DNAs derived from marrow samples. The primary endpoint was the best response rate including complete (CR) and partial response (PR) with overall (OS) and event-free survival (EFS) as secondary endpoints. Best response was noted in 14 patients (26.4 %) out of 53 evaluated patients including 12 CR and two PR with median follow-up of 21.6 months. A total of 81 abnormal SNP lesions were found in 25 out of 61 patients (41.0 %). The patients carrying abnormal SNP lesions showed an inferior CR/PR rate (p = 0.002) and showed a trend of worse OS (p = 0.02 in univariate, p = 0.09 in multivariate) compared to those without SNP lesions, but not were associated with inferior EFS. The presence of abnormal SNP lesions in MDS was associated with adverse outcomes following decitabine therapy. Further study is strongly warranted to establish the role of SNP-A karyotyping in MDS. © 2012 Springer-Verlag Berlin Heidelberg.
DOI
10.1007/s00277-012-1635-7
Appears in Collections:
의과대학 > 의학과 > Journal papers
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