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Pharmacokinetic characteristics of capsaicin-loaded nanoemulsions fabricated with alginate and chitosan

Title
Pharmacokinetic characteristics of capsaicin-loaded nanoemulsions fabricated with alginate and chitosan
Authors
Choi A.Y.Kim C.-T.Park H.Y.Kim H.O.Lee N.R.Lee K.E.Gwak H.S.
Ewha Authors
곽혜선
SCOPUS Author ID
곽혜선scopus
Issue Date
2013
Journal Title
Journal of Agricultural and Food Chemistry
ISSN
0021-8561JCR Link
Citation
vol. 61, no. 9, pp. 2096 - 2102
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Nanotechnologies are being employed to enhance the stability and oral bioavailability of lipophilic substances, such as capsaicin. This study aimed to examine the pharmacokinetic properties of the formulated capsaicin-loaded nanoemulsions. A pharmacokinetic study was carried out using double-layer nanoemulsions fabricated with alginate and chitosan polymers and triple-layer nanoemulsions fabricated with chitosan/alginate polymers. Capsaicin nanoemulsions and capsaicin control (oleoresin capsicum) were administered to the rat at a dose of 10 mg/kg. A statistically significant difference was found in the area under the curve from time zero to time infinity (AUCinf) among formulations (p < 0.01). In comparison to the control group, the relative bioavailability of formulated nanoemulsions was up to 131.7. The AUCinf increased in a nano-size-dependent manner; as nano size decreased, AUCinf increased. IN comparison to the double-layer nanoemulsions, the triple-layer nanoemulsion showed a significantly increased volume of distribution, resulting in the increased clearance and decreased AUCinf. It was concluded that the formulated nanoemulsions could significantly enhance the bioavailabilty of capsaicin. © 2013 American Chemical Society.
DOI
10.1021/jf3052708
Appears in Collections:
약학대학 > 약학과 > Journal papers
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