View : 46 Download: 0

Alterations in cardiac DNA methylation in human dilated cardiomyopathy

Title
Alterations in cardiac DNA methylation in human dilated cardiomyopathy
Authors
Haas J.Frese K.S.Park Y.J.Keller A.Vogel B.Lindroth A.M.Weichenhan D.Franke J.Fischer S.Bauer A.Marquart S.Sedaghat-Hamedani F.Kayvanpour E.Kohler D.Wolf N.M.Hassel S.Nietsch R.Wieland T.Ehlermann P.Schultz J..-H.Dosch A.Mereles D.Hardt S.Backs J.Hoheisel J.D.Plass C.Katus H.A.Meder B.
Ewha Authors
박윤정
SCOPUS Author ID
박윤정scopus
Issue Date
2013
Journal Title
EMBO Molecular Medicine
ISSN
1757-4676JCR Link
Citation
vol. 5, no. 3, pp. 413 - 429
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Dilated cardiomyopathies (DCM) show remarkable variability in their age of onset, phenotypic presentation, and clinical course. Hence, disease mechanisms must exist that modify the occurrence and progression of DCM, either by genetic or epigenetic factors that may interact with environmental stimuli. In the present study, we examined genome-wide cardiac DNA methylation in patients with idiopathic DCM and controls. We detected methylation differences in pathways related to heart disease, but also in genes with yet unknown function in DCM or heart failure, namely Lymphocyte antigen 75 (LY75), Tyrosine kinase-type cell surface receptor HER3 (ERBB3), Homeobox B13 (HOXB13) and Adenosine receptor A2A (ADORA2A). Mass-spectrometric analysis and bisulphite-sequencing enabled confirmation of the observed DNA methylation changes in independent cohorts. Aberrant DNA methylation in DCM patients was associated with significant changes in LY75 and ADORA2A mRNA expression, but not in ERBB3 and HOXB13. In vivo studies of orthologous ly75 and adora2a in zebrafish demonstrate a functional role of these genes in adaptive or maladaptive pathways in heart failure. Dilated cardiomyopathy is one the most frequent heart muscle diseases, which is responsible for one third of all heart failure cases. Here, the authors show widespread changes in DNA methylation patterns responsible for the disease. © 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO.
DOI
10.1002/emmm.201201553
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE