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dc.contributor.author김희선-
dc.date.accessioned2016-08-28T10:08:34Z-
dc.date.available2016-08-28T10:08:34Z-
dc.date.issued2013-
dc.identifier.issn0006-291X-
dc.identifier.otherOAK-9837-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/223503-
dc.description.abstractMicroglial activation plays an important role in neurodegenerative diseases. Thus, controlling microglial activation is considered to be a promising therapeutic target for neurodegenerative diseases. In the present study, we found that lancemaside A, a triterpenoid saponin isolated from Codonopsis lanceolata, inhibited iNOS and proinflammatory cytokines in LPS-stimulated BV2 microglial cells. By analyzing molecular mechanisms underlying the anti-inflammatory effects of lancemaside A, we found that lancemaside A selectively inhibited LPS-induced JNK phosphorylation among the three types of MAP kinases. A JNK-specific inhibitor, SP600125, like lancemaside A, significantly inhibited not only NO, TNF-α, and IL-6 productions, but also NF-κB and AP-1 activities, suggesting that JNK inhibition is largely involved in the anti-inflammatory mechanism of lancemaside A. Interestingly, both the lancemaside A and SP600125 inhibited ROS production by suppressing the expression and/or phosphorylation of NADPH oxidase subunit proteins, such as p47phox, p67phox, and gp91phox. The antioxidant effects of lancemaside A and SP600125 appear to be related with an increase of hemeoxygenase-1 expression by both agents. Finally, we demonstrated the neuroprotective effects of lancemaside A and SP600125 in microglia-neuron coculture systems. Collectively, our data suggest that JNK pathway plays a key role mediating anti-inflammatory effects of lancemaside A in LPS-stimulated microglia. © 2013 Elsevier Inc.-
dc.languageEnglish-
dc.titleLancemaside A inhibits microglial activation via modulation of JNK signaling pathway-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume431-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage369-
dc.relation.lastpage375-
dc.relation.journaltitleBiochemical and Biophysical Research Communications-
dc.identifier.doi10.1016/j.bbrc.2013.01.049-
dc.identifier.wosidWOS:000315842800001-
dc.identifier.scopusid2-s2.0-84873716660-
dc.author.googleJeong Y.-H.-
dc.author.googleJung J.-S.-
dc.author.googleLe T.K.V.-
dc.author.googleKim D.-H.-
dc.author.googleKim H.-S.-
dc.contributor.scopusid김희선(56431262700)-
dc.date.modifydate20180329110809-
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의과대학 > 의학과 > Journal papers
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