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Synthesis and physicochemical properties of new tripodal amphiphiles bearing fatty acids as a hydrophobic group

Title
Synthesis and physicochemical properties of new tripodal amphiphiles bearing fatty acids as a hydrophobic group
Authors
Avaji P.G.Jadhav V.B.Cui J.X.Jun Y.J.Lee H.J.Sohn Y.S.
Ewha Authors
손연수이화정전용주
SCOPUS Author ID
손연수scopus; 이화정scopus
Issue Date
2013
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 23, no. 6, pp. 1763 - 1767
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Saturated fatty acids (FA) were grafted using tyrosine as a spacer group to the cyclotriphosphazene ring along with equimolar hydrophilic methoxy poly(ethylene glycol) (MPEG) in cis-nongeminal way. Seven new cyclotriphosphazene amphiphiles were prepared from combinations of hydrophilic MPEGs with different molecular weights of 350, 550, 750 and 1000 and four different fatty acids of different hydrophobicity including lauric, myristic, palmitic and stearic acids. These steric amphiphiles bearing fatty acids as a hydrophobic group were found to form more stable micelles with very low critical micelle concentrations (CMC) (2.95-7.80 mg/L) compared with oligopeptide analogues, and their highly hydrophobic core environment is unique and potentially useful for various biomedical applications. © 2013 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2013.01.052
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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