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SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action

Title
SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action
Authors
Oh Y.-S.Gao P.Lee K.-W.Ceglia I.Seo J.-S.Zhang X.Ahn J.-H.Chait B.T.Patel D.J.Kim Y.Greengard P.
Ewha Authors
안정혁
SCOPUS Author ID
안정혁scopus
Issue Date
2013
Journal Title
Cell
ISSN
0092-8674JCR Link
Citation
vol. 152, no. 4, pp. 831 - 843
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
p11, through unknown mechanisms, is required for behavioral and cellular responses to selective serotonin reuptake inhibitors (SSRIs). We show that SMARCA3, a chromatin-remodeling factor, is a target for the p11/annexin A2 heterotetrameric complex. Determination of the crystal structure indicates that SMARCA3 peptide binds to a hydrophobic pocket in the heterotetramer. Formation of this complex increases the DNA-binding affinity of SMARCA3 and its localization to the nuclear matrix fraction. In the dentate gyrus, both p11 and SMARCA3 are highly enriched in hilar mossy cells and basket cells. The SSRI fluoxetine induces expression of p11 in both cell types and increases the amount of the ternary complex of p11/annexin A2/SMARCA3. SSRI-induced neurogenesis and behavioral responses are abolished by constitutive knockout of SMARCA3. Our studies indicate a central role for a chromatin-remodeling factor in the SSRI/p11 signaling pathway and suggest an approach to the development of improved antidepressant therapies. PaperClip: © 2013 Elsevier Inc.
DOI
10.1016/j.cell.2013.01.014
Appears in Collections:
의과대학 > 의학과 > Journal papers
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