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Aspirin-intolerant asthma in the Korean population: Prevalence and characteristics based on a questionnaire survey

Title
Aspirin-intolerant asthma in the Korean population: Prevalence and characteristics based on a questionnaire survey
Authors
Moon J.-Y.Kim S.-H.Kim T.-B.Chang Y.-S.Lee J.H.Cho Y.S.Park J.W.Jang A.-S.Park C.-S.Nahm D.-H.Cho Y.-J.Cho S.-H.Choi B.-W.Moon H.-B.Yoon H.J.
Ewha Authors
조영주
SCOPUS Author ID
조영주scopus
Issue Date
2013
Journal Title
Respiratory Medicine
ISSN
0954-6111JCR Link
Citation
vol. 107, no. 2, pp. 202 - 208
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: Aspirin-intolerant asthma is a unique clinical syndrome characterized by acute bronchoconstriction following the administration of aspirin and/or non-steroidal anti-inflammatory drugs. Objective: We assessed the prevalence and investigated the demographic and clinical characteristics of adult patients with aspirin-intolerant asthma in Korea. Methods: Using an adult asthma cohort (COREA) from 11 university hospitals in Korea, we analyzed the prevalence of aspirin-intolerant asthma, defined as a positive response to the question: "Have you ever experienced dyspnea and cough after taking an aspirin or any NSAID (cold medicine)?" Demographic and clinical characteristics were compared between patients with aspirin-intolerant asthma and aspirin-tolerant asthma. Results: Aspirin-intolerant asthma was reported in 68 (5.8%) of 1173 adult asthmatics (age 15-84). Patients with aspirin-intolerant asthma had a lower mean age (43.9 ± 13.4 vs. 49.0 ± 15.6, P = 0.003) and a higher prevalence of rhinosinusitis (77.9% vs. 61.7%, P = 0.012) and atopic dermatitis (16.2% vs. 5.7%, P = 0.001) than aspirin-tolerant asthma patients. There were no significant differences in lung function, asthma severity or the use of asthma controllers. However, aspirin-intolerant asthma was associated with greater use of healthcare services over a lifetime and over the past 12 months. Aspirin-intolerant asthma was significantly associated with emergency room visits over the past 12 months (P = 0.029, OR 2.19, 95% CI 1.08-4.42). Conclusion: Based on histories, the prevalence of aspirin-intolerant asthma is 5.8% among adult asthma patients in Korea. Aspirin-intolerant asthma is associated with lower age, higher prevalence of rhinosinusitis and atopic dermatitis, and more frequent exacerbations.© 2012 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.rmed.2012.10.020
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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