View : 26 Download: 0

2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6- dihydrothieno[2,3-h] quinoline derivatives for topoisomerase i and II inhibitory activity, cytotoxicity, and structure-activity relationship study

Title
2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6- dihydrothieno[2,3-h] quinoline derivatives for topoisomerase i and II inhibitory activity, cytotoxicity, and structure-activity relationship study
Authors
Thapa P.Karki R.Yoo H.Y.Park P.-H.Lee E.Jeon K.-H.Na Y.Cho W.-J.Kwon Y.Lee E.-S.
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2012
Journal Title
Bioorganic Chemistry
ISSN
0045-2068JCR Link
Citation
vol. 40, no. 1, pp. 67 - 78
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Designed and synthesized thirty-two 2,4-diaryl-5,6-dihydro-1,10- phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives as rigid analogs of 2,4,6-trisubstituted pyridines were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Structure-activity relationship study showed that [2,2′;6′,2″]-terpyridine skeleton is important for the cytotoxicity against several human cancer cell lines. © 2011 Elsevier Inc. All rights reserved.
DOI
10.1016/j.bioorg.2011.09.001
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE