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Clinical characteristics of patients with tuberculosis-destroyed lung

Title
Clinical characteristics of patients with tuberculosis-destroyed lung
Authors
Rhee C.K.Yoo K.H.Lee J.H.Park M.J.Kim W.J.Park Y.B.Hwang Y.I.Kim Y.S.Jung J.Y.Moon J.Y.Rhee Y.K.Park H.K.Lim J.H.Park H.Y.Lee S.W.Kim Y.H.Lee S.H.Yoon H.K.Kim J.W.Kim J.S.Kim Y.K.Oh Y.M.Lee S.D.Kim H.J.
Ewha Authors
이진화
SCOPUS Author ID
이진화scopus
Issue Date
2013
Journal Title
International Journal of Tuberculosis and Lung Disease
ISSN
1027-3719JCR Link
Citation
vol. 17, no. 1, pp. 67 - 75+i
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
SETTING: Multicentre study. OBJECTIVE: To define the clinical characteristics of patients with tuberculosis (TB) destroyed lung due to past TB. DESIGN: We reviewed patients with TB-destroyed lung between May 2005 and June 2011. RESULTS: A total of 595 patients from 21 hospitals were enrolled. The mean age was 65.63 ± 0.47 (mean ± standard error); 60.5% were male. The mean number of lobes involved was 2.59 ± 0.05. Pleural thickening was observed in 54.1% of the patients. Mean forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, bronchodilator response and number of exacerbations per year were respectively 2.06 ± 0.03 l (61.26% ± 0.79), 1.16 ± 0.02 l (49.05% ± 0.84), 58.03% ± 0.70, 5.70% ± 0.34, and 0.40 ± 0.04. The number of lobes involved was significantly correlated with FVC and FEV1, and with the number of exacerbations per year. Use of long-acting muscarinic antagonists or long-acting beta-2 agonists plus inhaled corticosteroids resulted in bronchodilatory effects. Multivariable regression analysis showed that age, initial FEV1 (%) and number of exacerbations during follow-up were independent factors affecting change in FEV1. CONCLUSION: Decreased lung function with exacerbation, and progressive decline of FEV1 were observed in patients with TB-destroyed lung. © 2013 The Union.
DOI
10.5588/ijtld.12.0351
Appears in Collections:
의과대학 > 의학과 > Journal papers
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