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Clinical characteristics of patients with tuberculosis-destroyed lung
- Clinical characteristics of patients with tuberculosis-destroyed lung
- Rhee C.K.; Yoo K.H.; Lee J.H.; Park M.J.; Kim W.J.; Park Y.B.; Hwang Y.I.; Kim Y.S.; Jung J.Y.; Moon J.Y.; Rhee Y.K.; Park H.K.; Lim J.H.; Park H.Y.; Lee S.W.; Kim Y.H.; Lee S.H.; Yoon H.K.; Kim J.W.; Kim J.S.; Kim Y.K.; Oh Y.M.; Lee S.D.; Kim H.J.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- International Journal of Tuberculosis and Lung Disease
- International Journal of Tuberculosis and Lung Disease vol. 17, no. 1, pp. 67 - 75+i
- SCIE; SCOPUS
- Document Type
- SETTING: Multicentre study. OBJECTIVE: To define the clinical characteristics of patients with tuberculosis (TB) destroyed lung due to past TB. DESIGN: We reviewed patients with TB-destroyed lung between May 2005 and June 2011. RESULTS: A total of 595 patients from 21 hospitals were enrolled. The mean age was 65.63 ± 0.47 (mean ± standard error); 60.5% were male. The mean number of lobes involved was 2.59 ± 0.05. Pleural thickening was observed in 54.1% of the patients. Mean forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, bronchodilator response and number of exacerbations per year were respectively 2.06 ± 0.03 l (61.26% ± 0.79), 1.16 ± 0.02 l (49.05% ± 0.84), 58.03% ± 0.70, 5.70% ± 0.34, and 0.40 ± 0.04. The number of lobes involved was significantly correlated with FVC and FEV1, and with the number of exacerbations per year. Use of long-acting muscarinic antagonists or long-acting beta-2 agonists plus inhaled corticosteroids resulted in bronchodilatory effects. Multivariable regression analysis showed that age, initial FEV1 (%) and number of exacerbations during follow-up were independent factors affecting change in FEV1. CONCLUSION: Decreased lung function with exacerbation, and progressive decline of FEV1 were observed in patients with TB-destroyed lung. © 2013 The Union.
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