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Birth weight of Korean infants is affected by the interaction of maternal iron intake and GSTM1 polymorphism

Title
Birth weight of Korean infants is affected by the interaction of maternal iron intake and GSTM1 polymorphism
Authors
Hur J.Kim H.Ha E.-H.Park H.Ha M.Kim Y.Hong Y.-C.Chang N.
Ewha Authors
하은희장남수박혜숙김혜숙
SCOPUS Author ID
하은희scopus; 장남수scopus; 박혜숙scopus; 김혜숙scopus
Issue Date
2013
Journal Title
Journal of Nutrition
ISSN
0022-3166JCR Link
Citation
vol. 143, no. 1, pp. 67 - 73
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Excessive iron consumption during pregnancy can lead to increased oxidative stress in the maternal body, which may result in adverse pregnancy outcomes. Glutathione S-transferases (GSTs) originate from a superfamily of detoxifying enzymes that play a role in reducing xenobiotic compounds and oxidative stress. The aim of this study was to determine the relationship among GST gene expression, maternal iron intake during pregnancy, and neonatal birth weight. The study participants were 1087 Korean gravidas and their newborns recruited for the Mothers and Children's Environmental Health study between 2006 and 2010. A 24-h dietary recall interview was conducted to estimate iron intake; additional intake through nutritionalsupplements was thoroughly investigated. Deletion polymorphisms of GSTM1 and GSTT1 were genotyped using PCR. Dietary iron consumption during pregnancy was positively associated with birth weight in pregnant women who were GSTM1-present after adjustment for the following covariates: maternal age, prepregnancy BMI, mother's education level, log-transformed urinary cotinine level, infant gender, gestational age at term, log-transformed energy intake, parity, and the use of folic acidsupplements (P < 0.05). There were interactions between the GSTM1 genotype and iron intakes from animal foods (P < 0.05), diet (P < 0.05), and diet with supplements (P < 0.05). No relationship was found between maternal iron intake and birth weight for the GSTT1 polymorphism. This study demonstrates that increased iron consumption during pregnancy mayimprove infant birth weight for mothers who are GSTM1-present, but it might not be beneficial for mothers with the GSTM1-nullgenotype. © 2013 American Society for Nutrition.
DOI
10.3945/jn.112.161638
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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