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Blood lead level modifies the association between dietary antioxidants and oxidative stress in an urban adult population

Title
Blood lead level modifies the association between dietary antioxidants and oxidative stress in an urban adult population
Authors
Hong Y.-C.Oh S.-Y.Kwon S.-O.Park M.-S.Kim H.Leem J.-H.Ha E.-H.
Ewha Authors
하은희
SCOPUS Author ID
하은희scopus
Issue Date
2013
Journal Title
British Journal of Nutrition
ISSN
0007-1145JCR Link
Citation
vol. 109, no. 1, pp. 148 - 154
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Oxidative stress may be affected by lead exposure as well as antioxidants, yet little is known about the interaction between dietary antioxidants and blood lead levels (BLL) on oxidative stress level. We investigated the interaction between dietary antioxidants and BLL on oxidative stress level. As part of the Biomarker Monitoring for Environmental Health conducted in Seoul and Incheon, Korea, between April and December 2005, we analysed data from 683 adults (female = 47·4%, mean age 51·4 (sd 8·4) years) who had complete measures on BLL, dietary intakes and oxidative stress marker (urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG)). Dietary intakes were assessed by a validated semi-quantitative FFQ, BLL was measured using atomic absorption spectrophotometry, and 8-OHdG by ELISA. Multivariate linear regression analyses were used to evaluate the influence of BLL on the association between dietary antioxidants and 8-OHdG. Geometric means of BLL and 8-OHdG concentrations were 4·1 (sd 1·5) μg/dl and 5·4 (sd 1·9) μg/g creatinine, respectively. Increases of vitamins C and E were significantly associated with the decrease of log10 8-OHdG in the adults from the lowest quartile of the BLL group ( ≤ 3·18 μg/dl, geometric mean = 2·36 μg/dl) than those of the highest quartile BLL group (>5·36 μg/dl, geometric mean = 6·78 μg/dl). Regarding antioxidant-related foods, vegetables excluding kimchi showed a higher inverse relationship with 8-OHdG in the lowest quartile BLL group than the highest group. These findings suggest a rationale for lowering the BLL and increasing the intake of dietary antioxidants in the urban population in Korea. © 2012 The Authors.
DOI
10.1017/S0007114512000694
Appears in Collections:
의과대학 > 의학과 > Journal papers
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