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Antibacterial butenolides from the korean tunicate Pseudodistoma antinboja

Title
Antibacterial butenolides from the korean tunicate Pseudodistoma antinboja
Authors
Wang W.Kim H.Nam S.-J.Rho B.J.Kang H.
Ewha Authors
노분조
SCOPUS Author ID
노분조scopusscopus
Issue Date
2012
Journal Title
Journal of Natural Products
ISSN
0163-3864JCR Link
Citation
vol. 75, no. 12, pp. 2049 - 2054
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Six new (1, 2, and 5-8) and three known (3, 4, and 9) butenolide metabolites were isolated from the tunicate Pseudodistoma antinboja by activity-guided fractionations. The structures were elucidated by combined NMR and MS spectroscopic methods. These compounds were evaluated for their antibacterial activity, and most of them exhibited moderate to significant activity that selectively targeted Gram-positive strains and did not exhibit cytotoxicity in the MTT assay at 100 μM. Cadiolides 5-9 in particular exhibited significant antibacterial activity that was comparable to or even better than those of marketed drugs such as vancomycin and linezolid against all of the drug-resistant strains tested. © 2012 The American Chemical Society and American Society of Pharmacognosy.
DOI
10.1021/np300544a
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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