Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신윤용 | * |
dc.contributor.author | 김대기 | * |
dc.contributor.author | 김승원 | * |
dc.date.accessioned | 2016-08-28T10:08:13Z | - |
dc.date.available | 2016-08-28T10:08:13Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 0223-5234 | * |
dc.identifier.other | OAK-9577 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223285 | - |
dc.description.abstract | A series of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4] triazolo[1,5-a]pyridin-6-yl)thiazoles 12a-ab, 13a, 13b, and 18a-d has been synthesized and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. The N-(3-fluorobenzyl)-4-(6- methylpyridin-2-yl)-5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)thiazol-2-amine (12b) inhibited ALK5 phosphorylation with an IC50 value of 7.01 nM and showed 61% inhibition at 30 nM in a luciferase reporter assay using HaCaT cells permanently transfected with p3TP-luc reporter construct. © 2012 Elsevier Masson SAS. All rights reserved. | * |
dc.language | English | * |
dc.title | Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin- 2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-β type 1 receptor kinase inhibitors | * |
dc.type | Article | * |
dc.relation.volume | 57 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 74 | * |
dc.relation.lastpage | 84 | * |
dc.relation.journaltitle | European Journal of Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.ejmech.2012.09.011 | * |
dc.identifier.wosid | WOS:000312621700009 | * |
dc.identifier.scopusid | 2-s2.0-84867021810 | * |
dc.author.google | Krishnaiah M. | * |
dc.author.google | Jin C.H. | * |
dc.author.google | Sreenu D. | * |
dc.author.google | Subrahmanyam V.B. | * |
dc.author.google | Rao K.S. | * |
dc.author.google | Son D.-H. | * |
dc.author.google | Park H.-J. | * |
dc.author.google | Kim S.W. | * |
dc.author.google | Sheen Y.Y. | * |
dc.author.google | Kim D.-K. | * |
dc.contributor.scopusid | 신윤용(6603872711) | * |
dc.contributor.scopusid | 김대기(35083694200) | * |
dc.contributor.scopusid | 김승원(57254952700;57224916916) | * |
dc.date.modifydate | 20240118164500 | * |