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Complexation-induced biomimetic long range fibrous orientation in a rigid-flexible block copolymer thermogel

Title
Complexation-induced biomimetic long range fibrous orientation in a rigid-flexible block copolymer thermogel
Authors
Park M.H.Choi B.G.Jeong B.
Ewha Authors
정병문
SCOPUS Author ID
정병문scopus
Issue Date
2012
Journal Title
Advanced Functional Materials
ISSN
1616-301XJCR Link
Citation
vol. 22, no. 24, pp. 5118 - 5125
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The orientation of the organofibrous structure plays an important role not only in the biomineralization process but also in the extracellular matrix (ECM) of articular cartilage by providing cells with biomechanical cues. Here, it is reported that a long range nanofibrous orientation can be realized by a self-assembling ionic complex between (+)-charged amphiphilic peptide block copolymers with a rigida flexible block structure (polyalaninea PLX-polyalanine; PA-PLX-PA) and (-)-charged hyaluronic acid (HA). A biomimetic 3D culture system encapsulating chondrocytes is formed by a temperature-sensitive sol-to-gel transition of the PA-PLX-PA/HA complex aqueous solution, which provides-compatible microenvironment for the cells. The cell proliferation and biomarker expression for articular cartilage are significantly improved in the PA-PLX-PA/HA complex system relative to the PA-PLX-PA or the commercially available Matrigel systems. In particular, noticeable cell clustering is observed in the PA-PLX-PA/HA complex system with the long range nanofibrous structure. This research suggests a new method for developing a nanofibrous structure using an amphiphilic peptide block copolymer and demonstrates its potential uses as a unique biomimetic cell-culture matrix. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
DOI
10.1002/adfm.201201722
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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