Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김형래 | * |
dc.contributor.author | 정혜원 | * |
dc.contributor.author | 문혜성 | * |
dc.contributor.author | 정경아 | * |
dc.date.accessioned | 2016-08-28T10:08:10Z | - |
dc.date.available | 2016-08-28T10:08:10Z | - |
dc.date.issued | 2013 | * |
dc.identifier.issn | 1046-7408 | * |
dc.identifier.other | OAK-9551 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223260 | - |
dc.description.abstract | Problem: To characterize the genetic variation across the MMP-2 and TIMP-2 gene with the risk of advanced-stage endometriosis. Method of study: Ten single-nucleotide polymorphisms (SNPs) and haplotype associations between MMP-2 (9082A>G, 9152A>G, 105330C>T, 14931T>C, 15918T>C, 18796G>A, 19033G>A, 19218A>G, 25190A>G, and 28542C>T) and TMIP-2 gene (42138327C>T, 42141169G>A, 42144611A>G, 42152781C>T, 42155855G>A, 42175617C>T, 42181597G>A, 42183387T>C, 42196041G>C, and 42196430T>C) were examined in 201 patients and 183 controls. Results: In MMP-2, G/A haplotype of 9082A>G and 9152A>G in intron 2 was associated with a reduced risk of endometriosis (OR 0.7, 95% CI 0.5-1.0, P = 0.04). In TIMP-2, the CC genotype of 42196430T>C and C/C haplotype of 42196041G>C/42196430T>C in the promoter region showed an increased risk of endometriosis (OR 3.0, 95% CI 1.2-8.0, P = 0.02; OR 1.6, 95% CI 1.1-2.4, P = 0.02), and the CC genotype of 42183387T>C and the C/G/C haplotype of 42175617C>T/42181597G>A/42183387T>C in intron 1 were associated with a reduced risk (OR 0.5, 95% CI 0.3-0.97, P = 0.04; OR 0.6, 95% CI 0.4-0.95, P = 0.03). Conclusion: The MMP-2 and TIMP-2 polymorphisms are associated with advanced-stage endometriosis. Especially, the risk of endometriosis was different according to the genetic position in the TIMP-2 gene. © 2012 John Wiley & Sons A/S. | * |
dc.language | English | * |
dc.title | Association Between MMP-2 and TIMP-2 Gene Polymorphisms and Advanced-Stage Endometriosis in Korean Women | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 69 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 73 | * |
dc.relation.lastpage | 84 | * |
dc.relation.journaltitle | American Journal of Reproductive Immunology | * |
dc.identifier.doi | 10.1111/aji.12020 | * |
dc.identifier.wosid | WOS:000312242800009 | * |
dc.identifier.scopusid | 2-s2.0-84870739242 | * |
dc.author.google | Cho Y.J. | * |
dc.author.google | Kim N.H. | * |
dc.author.google | Jeong K.-A. | * |
dc.author.google | Lee J.Y. | * |
dc.author.google | Moon H.-S. | * |
dc.author.google | Kim H.-L. | * |
dc.author.google | Chung H.W. | * |
dc.contributor.scopusid | 김형래(57202558385;57219111690;57567109600) | * |
dc.contributor.scopusid | 정혜원(56499737200) | * |
dc.contributor.scopusid | 문혜성(14319143700) | * |
dc.contributor.scopusid | 정경아(13309069700) | * |
dc.date.modifydate | 20240415131357 | * |