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Prefrontal cortical deficits in type 1 diabetes mellitus: Brain correlates of comorbid depression

Prefrontal cortical deficits in type 1 diabetes mellitus: Brain correlates of comorbid depression
Lyoo I.K.Yoon S.Jacobson A.M.Hwang J.Musen G.Kim J.E.Simonson D.C.Bae S.Bolo N.Kim D.J.Weinger K.Lee J.H.Ryan C.M.Renshaw P.F.
Ewha Authors
김지은scopus; 류인균scopus
Issue Date
Journal Title
Archives of General Psychiatry
0003-990XJCR Link
vol. 69, no. 12, pp. 1267 - 1276
Context: Neural substrates that may be responsible for the high prevalence of depression in type 1 diabetes mellitus (T1DM) have not yet been elucidated. Objective: To investigate neuroanatomic correlates of depression in T1DM. Design: Case-control study using high-resolution brain magnetic resonance images. Settings: Joslin Diabetes Center and McLean Hospital, Massachusetts, and Seoul National University Hospital, South Korea. Participants: A total of 125 patients with T1DM (44 subjects with ≥1 previous depressive episodes [T1DM-depression group] and 81 subjects who had never experienced depressive episodes [T1DM-only group]), 23 subjects without T1DM but with 1 or more previous depressive episodes (depression group), and 38 healthy subjects (control group). Main Outcome Measures: Spatial distributions of cortical thickness for each diagnostic group were compared with the control group using a surface-based approach. Among patients with T1DM, associations between metabolic control measures and cortical thickness deficits were examined. Results: Thickness reduction in the bilateral superior prefrontal cortical regions was observed in the T1DM-depression, T1DM-only, and depression groups relative to the control group at corrected P<.01. Conjunction analyses demonstrated that thickness reductions related to the influence of T1DM and those related to past depressive episode influence were observed primarily in the superior prefrontal cortical region. Long-term glycemic control levels were associated with superior prefrontal cortical deficits in patients with T1DM (β=-0.19, P=.02). Conclusions: This study provides evidence that thickness reduction of prefrontal cortical regions in patients with T1DM, as modified by long-term glycemic control, could contribute to the increased risk for comorbid depression. ©2012 American Medical Association. All rights reserved.
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