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Variations in the number of CCL3L1 gene copies and Kawasaki disease in Korean children

Title
Variations in the number of CCL3L1 gene copies and Kawasaki disease in Korean children
Authors
Kim H.-E.Kim J.-J.Han M.K.Lee K.-Y.Song M.S.Lee H.-D.Kim D.S.Yu J.J.Park I.-S.Yun S.W.Hong Y.M.Jang G.Y.Lee J.-K.
Ewha Authors
홍영미
SCOPUS Author ID
홍영미scopus
Issue Date
2012
Journal Title
Pediatric Cardiology
ISSN
0172-0643JCR Link
Citation
vol. 33, no. 8, pp. 1259 - 1263
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
High-dose intravenous immunoglobulin (IVIG) therapy is the highly effective and standard treatment for Kawasaki disease (KD). However, ~20 % of KD patients have persistent fever or recurrence of fever after the initial IVIG treatment, which increases the risk for coronary artery lesions (CALs). Furthermore, the mechanism of IVIG resistance in KD patients still is unknown. The number of CC chemokine ligand 3-like 1 (CCL3L1) gene copies is reported to be associated with KD and IVIG resistance in Japanese patients. In addition, the authors observed significant upregulation of the CCL3L1 gene expression after in vitro immunoglobulin treatment in B cell lines derived from KD patients. Therefore, this study of 459 KD patients and 496 healthy control subjects tested whether the number of CCL3L1 gene copies is associated with a risk of KD, CALs, and/or IVIG resistance in Korean KD patients. However, the number of CCL3L1 gene copies was not associated with KD (P = 0.18), CAL formation (P = 0.062), or the IVIG resistance (P = 0.90). Therefore, the results indicate that the number of CCL3L1 gene copies does not have a role in susceptibility to KD or CALs nor with IVIG resistance in Korean KD patients. © 2012 Springer Science+Business Media, LLC.
DOI
10.1007/s00246-012-0289-5
Appears in Collections:
의과대학 > 의학과 > Journal papers
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