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Serum levels of zinc, calcium, and iron are associated with the risk of preeclampsia in pregnant women

Title
Serum levels of zinc, calcium, and iron are associated with the risk of preeclampsia in pregnant women
Authors
Kim J.Kim Y.J.Lee R.Moon J.H.Jo I.
Ewha Authors
김영주이레나조인호
SCOPUS Author ID
김영주scopus; 이레나scopus; 조인호scopus
Issue Date
2012
Journal Title
Nutrition Research
ISSN
0271-5317JCR Link
Citation
vol. 32, no. 10, pp. 764 - 769
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Evidence indicates that various elements, including antioxidant minerals, might play an important role in preeclampsia (PE). This study was carried out to investigate the relationship between serum mineral levelsof zinc, calcium, iron, and selenium and the risk of preeclampsia in Korean women. Twenty-nine normal controls and 30 women with preeclampsia were recruited for the study. Preeclampsia was defined as having high blood pressure (≥140/90 mm Hg after 20 weeks gestation) and proteinuria (≥300 mg/24 hours). Serum mineral content was determined by instrumental neutron activation analysis. Serum zinc (P < .0001) and calcium (P = .0188) levels were lower in women with preeclampsia than those of normal women, while serum iron was significantly higher in women with preeclampsia (P = .0045). The odds ratio for preeclampsia was lower in women with higher serum zinc levels than those with lower levels after adjustment for age, height, and weight before delivery (P < .0001). The adjusted odds ratio for preeclampsia also decreased across tertiles of serum calcium concentration (P = .0452). However, there was an increased adjusted odds ratio for preeclampsia across tertiles of serum iron level (P = .0104). These results suggest that levels of serum minerals such as zinc, calcium, and iron may be associated with the risk of preeclampsia in Korean pregnant women. © 2012 Elsevier Inc.
DOI
10.1016/j.nutres.2012.09.007
Appears in Collections:
의과대학 > 의학과 > Journal papers
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