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Acute resveratrol treatment modulates multiple signaling pathways in the ischemic brain

Title
Acute resveratrol treatment modulates multiple signaling pathways in the ischemic brain
Authors
Shin J.A.Lee K.-E.Kim H.-S.Park E.-M.
Ewha Authors
이경은김희선박은미신진아
SCOPUS Author ID
이경은scopus; 김희선scopus; 박은미scopus; 신진아scopus
Issue Date
2012
Journal Title
Neurochemical Research
ISSN
0364-3190JCR Link
Citation
vol. 37, no. 12, pp. 2686 - 2696
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Resveratrol has several beneficial effects, including reductions of oxidative stress, inflammatory responses and apoptosis. It has been known that resveratrol is a sirtuin 1 (SIRT1) activator and protective effects of resveratrol are mediated by Akt and mitogen-activated protein kinases. However, it is not examined whether these pathways are regulated by resveratrol in the ischemic brain. Previously, we found that acute resveratrol treatment reduces brain injury induced by transient focal ischemic stroke. In the present study, we defined the signaling pathways modulated by resveratrol in ischemia by examining SIRT1 expression and phosphorylation of Akt, ERK1/2 and p38 in the ischemic cortex. Resveratrol increased expression of SIRT1 and phosphorylation of Akt and p38 but inhibited the increase in phosphorylation of ERK1/2. Gene and protein levels of peroxisome proliferator-activated receptor γ coactivator 1α, a downstream molecule of SIRT1, and mRNA levels of its target genes antioxidative superoxide dismutase 2 and uncoupling protein 2 were elevated. Resveratrol also increased phosphorylation of cyclic AMP-response-element-binding protein and transcription of the anti-apoptotic gene Bcl-2. These results suggest that various neuroprotective actions of resveratrol, including anti-oxidative, anti-apoptotic and inflammatory effects, are mediated via modulation of multiple signaling pathways in the ischemic brain. © Springer Science+Business Media, LLC 2012.
DOI
10.1007/s11064-012-0858-2
Appears in Collections:
의과대학 > 의학과 > Journal papers
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