Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이승진 | - |
dc.date.accessioned | 2016-08-28T10:08:01Z | - |
dc.date.available | 2016-08-28T10:08:01Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0944-7113 | - |
dc.identifier.other | OAK-9454 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223176 | - |
dc.description.abstract | Curcumin (diferuloylmethane) is a polyphenol derived from the plant turmeric (Curcuma longa), which is commonly used as a spice. Although anti-carcinogenic, anti-oxidant, anti-inflammation, and anti-angiogenic properties have been reported, the effect of curcumin on breast cancer metastasis is unknown. Matrix metalloproteinase-9 (MMP-9) is a major component in cancer cell invasion. In this study, we investigated the inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion and the molecular mechanisms involved in MCF-7 cells. Our results showed that curcumin inhibits TPA-induced MMP-9 expression and cell invasion through suppressing NF-κB and AP-1 activation. Also, curcumin strongly repressed the TPA-induced phosphorylation of p38 and JNK and inhibited TPA-induced translocation of PKCα from the cytosol to the membrane, but did not affect the translocation of PKCδ. These results indicate that curcumin-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the PKCα, MAPK and NF-κB/AP-1 pathway in MCF-7 cells. Curcumin may have potential value in restricting breast cancer metastasis. © 2012 Elsevier GmbH. All rights reserved. | - |
dc.language | English | - |
dc.title | Curcumin suppresses the TPA-induced invasion through inhibition of PKCα-dependent MMP-expression in MCF-7 human breast cancer cells | - |
dc.type | Article | - |
dc.relation.issue | 12 | - |
dc.relation.volume | 19 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1085 | - |
dc.relation.lastpage | 1092 | - |
dc.relation.journaltitle | Phytomedicine | - |
dc.identifier.doi | 10.1016/j.phymed.2012.07.002 | - |
dc.identifier.wosid | WOS:000311129000006 | - |
dc.identifier.scopusid | 2-s2.0-84866394314 | - |
dc.author.google | Kim J.-M. | - |
dc.author.google | Noh E.-M. | - |
dc.author.google | Kwon K.-B. | - |
dc.author.google | Kim J.-S. | - |
dc.author.google | You Y.-O. | - |
dc.author.google | Hwang J.-K. | - |
dc.author.google | Hwang B.-M. | - |
dc.author.google | Kim B.-S. | - |
dc.author.google | Lee S.-H. | - |
dc.author.google | Lee S.J. | - |
dc.author.google | Jung S.H. | - |
dc.author.google | Youn H.J. | - |
dc.author.google | Lee Y.-R. | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.date.modifydate | 20230201093329 | - |