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CD99 expression and newly diagnosed diffuse large B-cell lymphoma treated with rituximab-CHOP immunochemotherapy

Title
CD99 expression and newly diagnosed diffuse large B-cell lymphoma treated with rituximab-CHOP immunochemotherapy
Authors
Hong J.Park S.Park J.Jang S.J.Ahn H.K.Sym S.J.Cho E.K.Shin D.B.Lee J.H.
Ewha Authors
박상희
SCOPUS Author ID
박상희scopus
Issue Date
2012
Journal Title
Annals of Hematology
ISSN
0939-5555JCR Link
Citation
vol. 91, no. 12, pp. 1897 - 1906
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In order to evaluate prognostic value of CD99 expression in patients with diffuse large B-cell lymphoma (DLBCL) who underwent treatment with rituximab-CHOP immunochemotherapy, immunohistochemistry for CD99/ CD10/BCL-2/BCL-6/MUM-1 was performed on nodal DLBCL specimens from 70 patients. Patients were classified as either germinal center B-cell (GCB) subtype or non- GCB subtype according to the Muris algorithm. A superior 2-year event-free survival (EFS) was observed in patients with the GCB subgroup, compared to those with the non- GCB subgroup (p=0.034). The distribution of CD99 expression (29 patients; 41.4 %) did not show deviation according to subtype and was not prognostic for survival in the entire patient population. Among patients with the GCB subgroup, better EFS and overall survival (OS) were observed in CD99+ patients, compared to CD99? patients. Conversely, among patients with the non-GCB subgroup, inferior EFS and OS were reported in CD99+ patients. Superior 2-year EFS (p=0.004) and 2-year OS (p00.003) were observed in patients with GCB/CD99+ and non-GCB/ CD99? compared to the others, and the combination classification was found to be an independent prognostic factor. © 2012 Springer-Verlag.
DOI
10.1007/s00277-012-1533-z
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의과대학 > 의학과 > Journal papers
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