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Better survival of random pattern skin flaps through the use of epigallocatechin gallate

Title
Better survival of random pattern skin flaps through the use of epigallocatechin gallate
Authors
Cheon Y.W.Tark K.C.Kim Y.W.
Ewha Authors
김양우전영우
SCOPUS Author ID
김양우scopus
Issue Date
2012
Journal Title
Dermatologic Surgery
ISSN
1076-0512JCR Link
Citation
vol. 38, no. 11, pp. 1835 - 1842
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background Surgical skin flaps are useful, but flap necrosis is a common problem. Epigallocatechin gallate (EGCG), the major polyphenol of green tea, has been investigated as a neovascularization agent to counteract necrosis. Objectives To evaluate the effect of EGCG on random pattern skin flap survival. Materials and Methods The rat dorsal skin flap model was employed. One hundred rats were divided into five groups of equal size. Experimental Group A received local injection of EGCG to the flap, experimental Group B received topical application of EGCG, control Group C received local injection of saline, control Group D received topical application of an acetone-olive oil mixture, and control Group E received no treatment. The surviving area of the flap, regional blood perfusion, capillary density, and vascular endothelial growth factor (VEGF) expression were evaluated. Results We observed a larger area of skin flap survival in Groups A and B than in the control groups. Doppler measurement showed greater perfusion in Groups A and B, and the capillary density and VEGF expression were significantly higher in the experimental animals. Conclusion The EGCG treatment enhanced neovascularization and regional perfusion and, as a result, improved skin flap survival. © 2012 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.
DOI
10.1111/j.1524-4725.2012.02566.x
Appears in Collections:
의과대학 > 의학과 > Journal papers
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