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dc.contributor.author김형래-
dc.contributor.author성연아-
dc.contributor.author이혜진-
dc.date.accessioned2016-08-28T10:08:58Z-
dc.date.available2016-08-28T10:08:58Z-
dc.date.issued2012-
dc.identifier.issn1434-5161-
dc.identifier.otherOAK-9363-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/223130-
dc.description.abstractTo investigate the role of genetic predisposition in the pathogenesis of polycystic ovary syndrome (PCOS) in relation to obesity, we performed a genome-wide association study of PCOS in Koreans (n1741). PCOS is a heterogeneous endocrinal disorder of uncertain etiology. Obesity is one of the well-known risk factors for PCOS. Genome-wide association study. Women with or without PCOS. A total of 1881 samples were genotyped using Illumina HumanOmni1 Quad v1 and processed by R packages. The PCOS patients were divided into two subgroups according to PCOS diagnostic criteria (Rotterdam and National Institutes of Health (NIH)). For PCOS-associated loci in the two definitions, we successfully confirmed significant associations of GYS2 for body mass index in the discovery stage. We further replicated pleiotropic associations of GYS2 in a childhood obesity study (n482) and in a gestational diabetes study (n1710), respectively. Our study provides a preliminary framework upon diverse genetic effects underlying PCOS in Korean women. A newly identified GYS2 gene as a predisposing factor of PCOS might expand understanding of the biological pathways in metabolic and endocrine regulation. © 2012 The Japan Society of Human Genetics All rights reserved.-
dc.languageEnglish-
dc.titleGenome-wide association study identifies GYS2 as a novel genetic factor for polycystic ovary syndrome through obesity-related condition-
dc.typeArticle-
dc.relation.issue10-
dc.relation.volume57-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage660-
dc.relation.lastpage664-
dc.relation.journaltitleJournal of Human Genetics-
dc.identifier.doi10.1038/jhg.2012.92-
dc.identifier.wosidWOS:000310526500007-
dc.identifier.scopusid2-s2.0-84867921300-
dc.author.googleHwang J.-Y.-
dc.author.googleLee E.-J.-
dc.author.googleJin Go M.-
dc.author.googleSung Y.-A.-
dc.author.googleLee H.J.-
dc.author.googleHeon Kwak S.-
dc.author.googleJang H.C.-
dc.author.googleSoo Park K.-
dc.author.googleLee H.-J.-
dc.author.googleByul Jang H.-
dc.author.googleSong J.-
dc.author.googlePark K.-H.-
dc.author.googleKim H.-L.-
dc.author.googleCho M.-C.-
dc.author.googleLee J.-Y.-
dc.contributor.scopusid김형래(35278256500)-
dc.contributor.scopusid성연아(18435369300)-
dc.contributor.scopusid이혜진(56192810300)-
dc.date.modifydate20180329110130-
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의과대학 > 의학과 > Journal papers
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