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dc.contributor.author유경하-
dc.contributor.author우소연-
dc.contributor.author박윤신-
dc.date.accessioned2016-08-28T10:08:55Z-
dc.date.available2016-08-28T10:08:55Z-
dc.date.issued2012-
dc.identifier.issn0006-291X-
dc.identifier.otherOAK-9327-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/223106-
dc.description.abstractAllogenic bone marrow transplantation (BMT), an important treatment for hematological malignancies, is often complicated by graft-versus-host disease (GVHD). Suppression of GVHD is associated with the unwanted diminishment of the graft-versus-leukemia (GVL) response. The aim of this study was to maintain the benefits of GVL during GVHD suppression through isolated blockade of T-cell migration factors. To this end, we developed a murine model of B-cell leukemia, which was treated with BMT to induce GVHD. Within this model, functional blockade of MIP-2/CXCR2 was analyzed by observing proteomic, histologic and clinical variables of GVHD manifestation. Luminex assay of collected tissue identified several cytokines [granulocyte colony-stimulating factor (G-CSF), keratinocyte-derived chemokine (KC), macrophage inflammatory protein-2 (MIP-2), and interleukin-23 (IL-23)] that were upregulated during GHVD, but reduced by neutralizing the MIP-2/CXCR2 axis. In addition, donor T-cell blockade of CXCR2 combined with recipient administration of anti-MIP-2 caused a significant decrease in GVHD while preserving the GVL response. We propose that blocking the MIP-2/CXCR2 axis represents a novel strategy to separate the toxicity of GVHD from the beneficial effects of GVL after allogenic BMT. © 2012 Elsevier Inc.-
dc.languageEnglish-
dc.titleMacrophage inflammatory protein-2 (MIP-2)/CXCR2 blockade attenuates acute graft-versus-host disease while preserving graft-versus-leukemia activity-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume426-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage558-
dc.relation.lastpage564-
dc.relation.journaltitleBiochemical and Biophysical Research Communications-
dc.identifier.doi10.1016/j.bbrc.2012.08.126-
dc.identifier.wosidWOS:000310101000020-
dc.identifier.scopusid2-s2.0-84867220572-
dc.author.googleCho K.-A.-
dc.author.googleWoo S.-Y.-
dc.author.googlePark Y.S.-
dc.author.googlePark M.H.-
dc.author.googleRyu K.-H.-
dc.contributor.scopusid유경하(14038236200)-
dc.contributor.scopusid우소연(7402853365)-
dc.contributor.scopusid박윤신(35975370400;55915686100)-
dc.date.modifydate20180329110554-
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의과대학 > 의학과 > Journal papers
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