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The WNK/SPAK and IRBIT/PP1 pathways in epithelial fluid and electrolyte Transport

Title
The WNK/SPAK and IRBIT/PP1 pathways in epithelial fluid and electrolyte Transport
Authors
Park S.Hong J.H.Ohana E.Muallem S.
Ewha Authors
박성희
SCOPUS Author ID
박성희scopus
Issue Date
2012
Journal Title
Physiology
ISSN
1548-9213JCR Link
Citation
vol. 27, no. 5, pp. 291 - 299
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Fluid and electrolyte homeostasis is a fundamental physiological function required for survival and is associated with a plethora of diseases when aberrant. Systemic fluid and electrolyte composition is regulated by the kidney, and all secretory epithelia generate biological fluids with defined electrolyte composition by vectorial transport of ions and the obligatory water. A major regulatory pathway that immerged in the last several years is regulation of ion transporters by the WNK/SPAK kinases and IRBIT/PP1 pathways. The IRBIT/PP1 pathway functions to reverse the effects of the WNK/SPAK kinases pathway, as was demonstrated for NBCe1-B and CFTR. Since many transporters involved in fluid and electrolyte homeostasis are affected by PP1 and/or calcineurin, it is possible that WNK/SPAK and IRBIT/PP1 form a common regulatory pathway to tune the activity of fluid and electrolyte transport in response to physiological demands. ©2012 Int. Union Physiol. Sci./Am. Physiol. Soc.
DOI
10.1152/physiol.00028.2012
Appears in Collections:
의과대학 > 의학과 > Journal papers
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