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Prognostic factors in primary diffuse large B-cell lymphoma of adrenal gland treated with rituximab-CHOP chemotherapy from the Consortium for Improving Survival of Lymphoma (CISL)

Title
Prognostic factors in primary diffuse large B-cell lymphoma of adrenal gland treated with rituximab-CHOP chemotherapy from the Consortium for Improving Survival of Lymphoma (CISL)
Authors
Kim Y.R.Kim J.S.Min Y.H.Hyunyoon D.Shin H.-J.Mun Y.-C.Park Y.Do Y.R.Jeong S.H.Park J.S.Oh S.Y.Lee S.Park E.K.Jang J.-S.Lee W.-S.Lee H.-W.Eom H.Ahn J.-S.Jeong J.-H.Baek S.K.Kim S.J.Kim W.S.Suh C.
Ewha Authors
문영철
SCOPUS Author ID
문영철scopus
Issue Date
2012
Journal Title
Journal of Hematology and Oncology
ISSN
1756-8722JCR Link
Citation
vol. 5
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: The objective of this study was to identify prognostic factors for survival in patients with primary diffuse large B-cell lymphoma (DLBCL) of the adrenal gland. Methods: Thirty one patients diagnosed with primary adrenal DLBCL from 14 Korean institutions and treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) were analyzed. Results: Complete remission (CR) and overall response rate after R-CHOP chemotherapy were 54.8% and 87.0%. The 2-year estimates of overall survival (OS) and progression-free survival (PFS) were 68.3% and 51.1%. In patients achieving CR, significant prolongations of OS (P = 0.029) and PFS (P = 0.005) were observed. Ann Arbor stage had no influence on OS. There was no significant difference in OS between patients with unilateral involvement of adrenal gland and those with bilateral involvement. When staging was modified to include bilateral adrenal involvement as one extranodal site, early stage (I or II) significantly correlated with longer OS (P = 0.021) and PFS (P <0.001). Conclusions: Contrary to prior reports, our data suggests that outcomes of primary adrenal DLBCL are encouraging using a regimen of R-CHOP, and that achieving CR after R-CHOP is predictive of survival. Likewise, our modified staging system may have prognostic value. © 2012 Kim et al.; licensee BioMed Central Ltd.
DOI
10.1186/1756-8722-5-49
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의과대학 > 의학과 > Journal papers
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