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A straightforward synthesis of K-7174, a GATA-specific inhibitor

Title
A straightforward synthesis of K-7174, a GATA-specific inhibitor
Authors
Majik M.S.Yu J.H.Jeong L.S.
Ewha Authors
정낙신
Issue Date
2012
Journal Title
Bulletin of the Korean Chemical Society
ISSN
0253-2964JCR Link
Citation
vol. 33, no. 9, pp. 2903 - 2906
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
K-7174, a GATA-specific inhibitor, is a putative anti-inflammatory agent that attenuates effects of inflammatory cytokines in certain cell types. An expeditious four-step synthesis of K-7174 is described in this paper. The route employs Wittig olefination and bis-alkylation of homopiperazine as the key reactions. The iodinecatalyzed isomerization of the Z-isomer results in complete conversion to the E-isomer is the highlight of our synthetic endeavors.
DOI
10.5012/bkcs.2012.33.9.2903
Appears in Collections:
약학대학 > 약학과 > Journal papers
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