Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 허정원 | * |
dc.contributor.author | 문영철 | * |
dc.date.accessioned | 2016-08-28T10:08:47Z | - |
dc.date.available | 2016-08-28T10:08:47Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 0361-8609 | * |
dc.identifier.other | OAK-9242 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223031 | - |
dc.description.abstract | Core binding factor (CBF) AML with the D816 C-KIT gene mutation demonstrate inferior treatment outcomes. However, the remaining cases without the D816 C-KIT mutation imply a requirement of more sophisticated dissection of the patients according to their prognosis. In this study, we analyzed the prognostic value of a single nucleotide polymorphism array (SNP-A) based karyotyping combined with metaphase cytogenetics (MC) to facilitate further stratification of CBF AML patients. A total of 98 CBF AML patients were included and genome-wide Human SNP 6.0 Arrays (Affymetrix) were performed using marrow samples taken at diagnosis. Overall, 40 abnormal lesions were identified in 25 patients (26%). Survival of the patients with the abnormal lesion(s) detected by SNP-A and/or MC was worse than those without lesions in terms of the 2-year overall survival (OS; 57.5% vs. 76.4%, P = 0.028), event-free (EFS; 45.7% vs. 66.2%, P = 0.072), and leukemia-free survival (LFS; 49.0% vs. 77.4%, P = 0.015), specially in the subgroup with inv(16)/t(16;16) (40.9% vs. 80.2% OS, P = 0.040) and in the subgroup without the D816 C-KIT mutation (61.6% vs. 82.7% OS, P = 0.038). Multivariate analysis confirmed the prognostic impact of the abnormal SNP-A and/or MC lesion on EFS (HR 2.011, P = 0.047), and LFS (HR 3.231, P = 0.005) in the overall CBF AML. This study suggests that the combined use of SNP-A with MC in the CBF AML can provide important prognostic value, especially in the inv(16)/t(16;16) subgroup or in the patients without the D816 C-KIT mutation. © 2012 Wiley Periodicals, Inc. | * |
dc.language | English | * |
dc.title | A genome-wide single-nucleotide polymorphism-array can improve the prognostic stratification of the core binding factor acute myeloid leukemia | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 87 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 961 | * |
dc.relation.lastpage | 968 | * |
dc.relation.journaltitle | American Journal of Hematology | * |
dc.identifier.doi | 10.1002/ajh.23281 | * |
dc.identifier.wosid | WOS:000309065700082 | * |
dc.identifier.scopusid | 2-s2.0-84866752027 | * |
dc.author.google | Huh J. | * |
dc.author.google | Kim H.-J. | * |
dc.author.google | Jung C.W. | * |
dc.author.google | Kim S.-H. | * |
dc.author.google | Kim Y.-K. | * |
dc.author.google | Shin M.G. | * |
dc.author.google | Moon J.H. | * |
dc.author.google | Sohn S.K. | * |
dc.author.google | Kim S.H. | * |
dc.author.google | Lee W.S. | * |
dc.author.google | Won J.H. | * |
dc.author.google | Mun Y.C. | * |
dc.author.google | Kim H. | * |
dc.author.google | Park J. | * |
dc.author.google | Min W.S. | * |
dc.author.google | Kim D.H. | * |
dc.contributor.scopusid | 허정원(7102258576) | * |
dc.contributor.scopusid | 문영철(7003363716) | * |
dc.date.modifydate | 20240422115947 | * |