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dc.contributor.author이서구-
dc.contributor.author배수한-
dc.contributor.author길인섭-
dc.contributor.author우현애-
dc.date.accessioned2016-08-28T10:08:45Z-
dc.date.available2016-08-28T10:08:45Z-
dc.date.issued2012-
dc.identifier.issn1523-0864-
dc.identifier.otherOAK-9219-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/223010-
dc.description.abstractAims: To define the mechanisms underlying pyrazole-induced oxidative stress and the protective role of peroxiredoxins (Prxs) and sulfiredoxin (Srx) against such stress. Results: Pyrazole increased Srx expression in the liver of mice in a nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent manner and induced Srx translocation from the cytosol to the endoplasmic reticulum (ER) and mitochondria. Pyrazole also induced the expression of CYP2E1, a primary reactive oxygen species (ROS) source for ethanol-induced liver injury, in ER and mitochondria. However, increased CYP2E1 levels only partially accounted for the pyrazole-mediated induction of Srx, prompting the investigation of CYP2E1-independent ROS generation downstream of pyrazole. Indeed, pyrazole increased ER stress, which is known to elevate mitochondrial ROS. In addition, pyrazole upregulated CYP2E1 to a greater extent in mitochondria than in ER. Accordingly, among Prxs I to IV, PrxIII, which is localized to mitochondria, was preferentially hyperoxidized in the liver of pyrazole-treated mice. Pyrazoleinduced oxidative damage to the liver was greater in PrxIII -/- mice than in wild-type mice. Such damage was also increased in Srx -/- mice treated with pyrazole, underscoring the role of Srx as the guardian of PrxIII. Innovation: The roles of Prxs, Srx, and ER stress have not been previously studied in relation to pyrazole toxicity. Conclusion: The concerted action of PrxIII and Srx is important for protection against pyrazole-induced oxidative stress arising from the convergent induction of CYP2E1-derived and ER stress-derived ROS in mitochondria. © 2012 Mary Ann Liebert, Inc.-
dc.languageEnglish-
dc.titlePeroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injury-
dc.typeArticle-
dc.relation.issue10-
dc.relation.volume17-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1351-
dc.relation.lastpage1361-
dc.relation.journaltitleAntioxidants and Redox Signaling-
dc.identifier.doi10.1089/ars.2011.4334-
dc.identifier.wosidWOS:000308804200002-
dc.identifier.scopusid2-s2.0-84866286088-
dc.author.googleBae S.H.-
dc.author.googleSung S.H.-
dc.author.googleLee H.E.-
dc.author.googleKang H.T.-
dc.author.googleLee S.K.-
dc.author.googleOh S.Y.-
dc.author.googleWoo H.A.-
dc.author.googleKil I.S.-
dc.author.googleRhee S.G.-
dc.contributor.scopusid이서구(7401852092;25923074700)-
dc.contributor.scopusid우현애(8068619500)-
dc.date.modifydate20180302081000-
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일반대학원 > 생명·약학부 > Journal papers
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