Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 서정완 | * |
dc.contributor.author | 조민선 | * |
dc.date.accessioned | 2016-08-28T10:08:45Z | - |
dc.date.available | 2016-08-28T10:08:45Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 1093-5266 | * |
dc.identifier.other | OAK-9218 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/223009 | - |
dc.description.abstract | Despite an intensive pro-inflammatory response, the immune system is unable to clear the organism in Helicobacter pylori gastritis. Regulatory T (Treg) cells, which suppress the immune response of antigen-specific T cells, have recently been demonstrated to play a key role in chronic inflammation by immunologic tolerance. The purpose of our study was to investigate the histopathology, FOXP3+CD4+CD25highTreg (FOXP3+ Treg) cell expression, and immune responses in children with H. pylori infection. Twenty-four H. pylori-positive and 24 H. pylori-negative children who underwent esophagogastroduodenoscopy for dyspeptic symptoms were included. Histopathologic grading according to the updated Sydney classification and immunohistochemical stains for FOXP3, transforming growth factor- β1 (TGF-β1), and CD4 were performed. Histopathologic bacterial density score, gastritis activity score, and chronic inflammation score were higher in the H. pylori-positive group than in the negative group (P < 0.01). The number of FOXP3+Treg cells and CD4 +T cells and the grade of TGF-β1 expression were significantly increased in the H. pylori-positive group compared to the negative group (P < 0.01). The number of FOXP3+Treg cells correlated positively with the grade of TGF-β1 expression regardless of H. pylori status (P < 0.05). The number of FOXP3+Treg cells and the grade of TGF-β1 expression correlated positively with H. pylori density, gastritis activity score, and chronic inflammation score regardless of H. pylori status (P < 0.01). These findings indicate that FOXP3+Treg cells could play a role in persistent H. pylori infection. © 2012 Society for Pediatric Pathology. | * |
dc.language | English | * |
dc.title | FOXP3+ regulatory T cells in children with Helicobacter pylori Infection | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 15 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 118 | * |
dc.relation.lastpage | 126 | * |
dc.relation.journaltitle | Pediatric and Developmental Pathology | * |
dc.identifier.doi | 10.2350/11-06-1046-OA.1 | * |
dc.identifier.wosid | WOS:000308802900006 | * |
dc.identifier.scopusid | 2-s2.0-84864143772 | * |
dc.author.google | Cho K.Y.Y. | * |
dc.author.google | Cho M.S. | * |
dc.author.google | Seo J.W. | * |
dc.contributor.scopusid | 서정완(36890595100) | * |
dc.contributor.scopusid | 조민선(13205279200) | * |
dc.date.modifydate | 20240118154227 | * |