Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김종학 | - |
dc.date.accessioned | 2016-08-28T10:08:43Z | - |
dc.date.available | 2016-08-28T10:08:43Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1072-3714 | - |
dc.identifier.other | OAK-9177 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222979 | - |
dc.description.abstract | Objective: The aim of this study was to explore the association between polymorphisms in Wnt antagonist genes and bone response to hormone therapy (HT) in postmenopausal Korean women. Methods: A prospective study was conducted with 303 postmenopausal women receiving sequential estrogen plus progestogen therapy in a university hospital. The dickkopf (Dkk) 1 c.318A>G, Dkk2 c.437G>A, Dkk3 c.1003A>G, secreted frizzled-related protein (sFRP) 1 rs3242C>T, rs16890444C>T, sFRP3 c.970C>G, sFRP4 c.958C>A, c.1019G>A, and sFRP5 c.20G>C polymorphisms were analyzed, and bone mineral density (BMD) at the lumbar spine and femoral neck (FN) was measured before and after 1 year of sequential estrogen plus progestogen therapy. Results: The percentage changes in BMD of the FN after 1 year of HT were found to be significantly (P < 0.05) different according to the haplotype genotype composed of the sFRP4 c.958C>A and c.1019G>A polymorphisms after adjustment for baseline BMD. The percentage change in BMD at the FN after 1 year of HT was significantly higher in the AA/AG haplotype genotype than in the AG/CG (P < 0.01) or CG/CG (P < 0.05) haplotype genotype. However, any single and combined polymorphisms measured were not related with nonresponsiveness to HT when a nonresponder was defined as a woman who had lost more than 3% of BMD per year after HT. Conclusions: The haplotype genotypes of sFRP4 c.958C>A and c.1019G>A polymorphisms are genetic factors that affect changes in BMD of the FN after HT in postmenopausal Korean women. © 2012 The North American Menopause Society. | - |
dc.language | English | - |
dc.title | The association between polymorphisms in Wnt antagonist genes and bone response to hormone therapy in postmenopausal Korean women | - |
dc.type | Article | - |
dc.relation.issue | 9 | - |
dc.relation.volume | 19 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1008 | - |
dc.relation.lastpage | 1014 | - |
dc.relation.journaltitle | Menopause | - |
dc.identifier.doi | 10.1097/gme.0b013e3182503d47 | - |
dc.identifier.wosid | WOS:000308415500012 | - |
dc.identifier.scopusid | 2-s2.0-84865711439 | - |
dc.author.google | Kim H. | - |
dc.author.google | Lee D.O. | - |
dc.author.google | Ku S.-Y. | - |
dc.author.google | Kim S.H. | - |
dc.author.google | Kim J.H. | - |
dc.author.google | Kim J.G. | - |
dc.contributor.scopusid | 김종학(55720161300) | - |
dc.date.modifydate | 20180901081003 | - |