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Antihypertensive treatment of acute intracerebral hemorrhage by intravenous nicardipine hydrochloride: Prospective multi-center study

Title
Antihypertensive treatment of acute intracerebral hemorrhage by intravenous nicardipine hydrochloride: Prospective multi-center study
Authors
Hwang S.-K.Kim J.-S.Kim J.H.Hong C.-K.Yang K.H.
Ewha Authors
황승균
SCOPUS Author ID
황승균scopus
Issue Date
2012
Journal Title
Journal of Korean Medical Science
ISSN
1011-8934JCR Link
Citation
vol. 27, no. 9, pp. 1085 - 1090
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
The authors performed a multicenter prospective study to evaluate the feasibility and safety of intravenous nicardipine hydrochloride for acute hypertension in patients with intracerebral hemorrhage (ICH). This study included 88 patients (mean age: 58.3 yr, range 26-87 yr) with ICH and acute hypertension in 5 medical centers between August 2008 and November 2010, who were treated using intravenous nicardipine. Administration of nicardipine resulted in a decrease from mean systolic blood pressure (BP) (175.4 ± 33.7 mmHg) and diastolic BP (100.8 ± 22 mmHg) at admission to mean systolic BP (127.4 ± 16.7 mmHg) and diastolic BP (67.2 ± 12.9 mmHg) in 6 hr after infusion (P < 0.001, mixed-effect linear models). Among patients who underwent follow-up by computed tomography, hematoma expansion at 24 hr (more than 33% increase in hematoma size at 24 hr) was observed in 3 (3.4%) of 88 patients. Neurological deterioration (defined as a decrease in initial Glasgow coma scale ≥ 2) was observed in 2 (2.2%) of 88 patients during the treatment. Aggressive nicardipine treatment of acute hypertension in patients with ICH can be safe and effective with a low rate of neurological deterioration and hematoma expansion. © 2012 The Korean Academy of Medical Sciences.
DOI
10.3346/jkms.2012.27.9.1085
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의과대학 > 의학과 > Journal papers
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