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Enhancement of anxiety and modulation of TH and pERK expressions in amygdala by repeated injections of corticosterone

Title
Enhancement of anxiety and modulation of TH and pERK expressions in amygdala by repeated injections of corticosterone
Authors
Lim H.Jang S.Lee Y.Moon S.Kim J.Oh S.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2012
Journal Title
Biomolecules and Therapeutics
ISSN
1976-9148JCR Link
Citation
vol. 20, no. 4, pp. 418 - 424
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Repeated stress induces corticosterone release. However, it is not clear that stress results in further elevation of corticosterone levels, and the roles of released corticosterone to aggravate stress-related symptoms are also not clear. This study investigated whether neuronal modulation was induced in the amygdala after two kinds of stress, that is, such as electric shock and corticosterone injection. It was found that stress by electric shock decreased the expression of tyrosine hydoroxylase (TH) in the amygdala while the expression of pERK was increased. However, there is no difference in the expressions of TH and pERK in the frontal cortex compared with those of the control group. The level of corticosterone was signifi cantly increased in the serum after stress. To determine the effect of corticosterone on the induction of anxiety and the expression of TH, the rats received corticosterone (20 mg or 40 mg/kg i.p.) for 1 day, 1 week, 2 weeks and 3 weeks, respectively. The spent time in open arms of the EPM (elevated plus maze) test was signifi cantly decreased after 1 week, 2 weeks and 3 weeks. The time spent in open arms of the EPM test after repeated injections of corticosterone was signifi cantly decreased in a dose-dependent manner. The expression of TH in the amygdala was reduced after following repeated corticosterone treatment for 2 weeks and 3 weeks. Collectively, this study suggests that corticosterone has a major role in the induction of anxiety and the modulation of TH expression, at least, in the amygdala. © 2012 The Korean Society of Applied Pharmacology.
DOI
10.4062/biomolther.2012.20.4.418
Appears in Collections:
의과대학 > 의학과 > Journal papers
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