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SIRT3 is a mitochondrial tumor suppressor: A scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis

Title
SIRT3 is a mitochondrial tumor suppressor: A scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis
Authors
Haigis M.C.Deng C.-X.Finley L.W.S.Kim H.-S.Gius D.
Ewha Authors
김현석
SCOPUS Author ID
김현석scopus
Issue Date
2012
Journal Title
Cancer Research
ISSN
0008-5472JCR Link
Citation
vol. 72, no. 10, pp. 2468 - 2472
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Tumors exhibit metabolic reprogramming characterized by increased cellular reactive oxygen species (ROS) and the preferential use of glucose, which is known as the Warburg effect. However, the mechanisms by which these processes are linked remain largely elusive. Murine tumors lacking Sirt3 exhibit abnormally high levels of ROS that directly induce genomic instability and increase hypoxia-inducible factor 1α(HIF-1α) protein levels. The subsequent transcription of HIFα-dependent target genes results in cellular metabolic reprogramming and increased cellular glucose consumption. In addition, agents that scavenge ROS or reverse the Warburg effect prevent the transformation and malignant phenotype observed in cells lacking Sirt3. Thus, mice lacking Sirt3 provide a model that mechanistically connects aberrant ROS, the Warburg effect, and carcinogenesis. ©2012 AACR.
DOI
10.1158/0008-5472.CAN-11-3633
Appears in Collections:
일반대학원 > 바이오융합과학과 > Journal papers
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