View : 25 Download: 0

Effect of different concentrations of escherichia Coli-derived rhBMP-2 coating on osseointegration of implants in dogs

Title
Effect of different concentrations of escherichia Coli-derived rhBMP-2 coating on osseointegration of implants in dogs
Authors
Lee Y.-J.Kim Y.Kim J.-Y.Huh J.-B.Kim M.-R.Kim S.-J.
Ewha Authors
김명래김선종김예미
SCOPUS Author ID
김명래scopus; 김선종scopus; 김예미scopus
Issue Date
2012
Journal Title
Tissue Engineering and Regenerative Medicine
ISSN
1738-2696JCR Link
Citation
vol. 9, no. 4, pp. 209 - 215
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
The aim of the present study was to evaluate the effect of different concentrations of Escherichia coliderived recombinant human BMP-2 (ErhBMP2) coating on osseointegration of implants (Cowellmedi, Pusan, Korea) in dogs. Three beagle dogs were used in this study. The lower premolars were extracted without causing bone destruction and cared for 8 weeks, which was considered as the bone healing period. The implants were coated with 4 different concentrations (0.1 mg/mL, 0.3 mg/mL, 0.5 mg/mL, and 1.0 mg/mL) of ErhBMP-2, and then installed in the extraction socket in the mandible and bone formation was assessed after 8 weeks. After the dogs were euthanized, histological samples were obtained and bone volume (BV) and bone-to-implant contact (BIC) were measured. The BV ratio was the highest in the ErhBMP-2 0.3 mg/mL group; however, the differences in the BV ratio between the treatment groups were not statistically significant. The level of BIC was higher in the ErhBMP-2 1.0 mg/mL group and the ErhBMP-2 0.3 mg/mL group than that in the other groups, but again the differences in the levels of BIC were not statistically significant. In addition, the level of BIC at all sites was relatively lower when compared to that in the previous studies. In this study, the ErhBMP-2 coating on the implants was not found to be useful for improving BV and BIC in the healthy alveolar bone. Further studies are needed to compare the level of BIC of the ErhBMP-2-coated implant and non-coated implant. © Springer, Part of Springer Science+Business Media.
DOI
10.1007/s13770-012-0319-7
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE