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The Clinical Significance of Serum Cystatin Cin Critically Ill Newborns With Normal Serum Creatinine

Title
The Clinical Significance of Serum Cystatin Cin Critically Ill Newborns With Normal Serum Creatinine
Authors
Cho S.Y.Hahn W.-H.Lee H.J.Suh J.-T.Lee A.Cho B.-S.Suh J.-S.
Ewha Authors
이안복
Issue Date
2012
Journal Title
Journal of Clinical Laboratory Analysis
ISSN
0887-8013JCR Link
Citation
vol. 26, no. 4, pp. 267 - 271
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: The aim of this study is to evaluate the clinical significance of cystatin C(CysC) in the newborns who show normal serum creatinine (Cr) and who are in an intensive care unit. Methods: From July 2009 to May 2010, a total of 106 patients (53 male and 53 female newborns) in a neonatal intensive care unit at Kyung Hee Medical Center were enrolled in this study. When clinicians ordered CysC, it was tested using HiSens Cystatin-C LTIA(HBi, An-yang, Korea) on a Toshiba chemical analyzer (Toshiba, Nasushiobara, Japan). Results: The range of serum Cr and CysCwas from 0.1 to 0.8 mg/dL and from 1.0 to 2.3 mg/L, respectively. CysCpresented the wider amplitude of the changes in acute renal failure. Conclusion: In this study, CysCwithout an increased Cr showed only a mild increase. However, CysCreflected more delicate changes in newborns than the serum Cr. This characteristic of CysCcould make it very appropriate for a pediatric population, especially for critically ill newborns. © 2012 Wiley Periodicals, Inc.
DOI
10.1002/jcla.21516
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의료원 > 의료원 > Journal papers
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