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Efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers: A meta-analysis

Title
Efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers: A meta-analysis
Authors
Myung S.-K.Ju W.Jung H.-S.Park C.-H.Oh S.-W.Seo H.G.Kim H.S.
Ewha Authors
주웅
SCOPUS Author ID
주웅scopus
Issue Date
2012
Journal Title
BJOG: An International Journal of Obstetrics and Gynaecology
ISSN
1470-0328JCR Link
Citation
vol. 119, no. 9, pp. 1029 - 1039
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background The efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers has not yet been established. Objective To investigate the efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers. Search strategy A search was made of PubMed, Embase and CENTRAL in June 2011. Selection criteria Randomised controlled trials (RCTs), quasi-RCTs and retrospective or prospective controlled studies were included. Data collection and analysis The main analyses were designed to examine the efficacy of pharmacotherapy for smoking cessation among pregnant smokers based on the longest follow-up data available and from data obtained at the latest available time-point in pregnancy in each study. Main results Of 74 articles identified from the databases, seven studies (five RCTs, one quasi-RCT and one prospective study) involving a total of 1386 pregnant smokers, 732 in the intervention groups and 654 in the control groups, were included in the final analyses. In a fixed-effects meta-analysis of all seven studies based on the longest follow-up data available, pharmacotherapy had a significant effect on smoking cessation (relative risk [RR] 1.80; 95% confidence interval [CI] 1.32-2.44). Subgroup meta-analysis by type of study design also showed similar findings for RCTs (RR 1.48; 95% CI 1.04-2.09) and other types of studies (RR 3.25; 95% CI 1.65-6.39). The abstinence rate at late pregnancy in the intervention ranged from 7 to 22.6% (mean abstinence rate 13.0%; 95% CI 10.9-15.2%). A few minor adverse effects and serious adverse effects were reported in several studies. Author's conclusions This study indicates that there may be clinical evidence to support the use of pharmacotherapy for smoking cessation among pregnant smokers. Further RCTs are needed. © 2012 RCOG.
DOI
10.1111/j.1471-0528.2012.03408.x
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의학전문대학원 > 의학과 > Journal papers
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