View : 22 Download: 0

Tonsil-derived mesenchymal progenitor cells acquire a follicular dendritic cell phenotype under cytokine stimulation

Title
Tonsil-derived mesenchymal progenitor cells acquire a follicular dendritic cell phenotype under cytokine stimulation
Authors
Cho K.-A.Kim J.-Y.Kim H.S.Ryu K.-H.Woo S.-Y.
Ewha Authors
유경하우소연김한수
SCOPUS Author ID
유경하scopus; 우소연scopus; 김한수scopus
Issue Date
2012
Journal Title
Cytokine
ISSN
1043-4666JCR Link
Citation
vol. 59, no. 2, pp. 211 - 214
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Tonsils comprise part of the mucosal immune system and contain lymphocytes, macrophages, and follicular dendritic cells (FDCs). FDCs are located in the B cell area of the follicles of secondary lymphoid organs, such as the spleen, tonsils, or lymph nodes, and they trap and retain immune complexes on their surfaces to regulate B cell activation and maturation. Stromal cells from the palatine tonsils are often used for FDC in vitro studies, and it has been reported that human palatine tonsils may be a good source of multipotent mesenchymal cells. Therefore, we assessed whether tonsil-derived mesenchymal stromal cells could differentiate into a FDC-like phenotype. We discovered that stromal cells isolated from human tonsils not only had the potential to differentiate into various cell types of mesenchymal origin, but they also could differentiate into FDC-like cells under cytokine stimulation in vitro. © 2012 Elsevier Ltd.
DOI
10.1016/j.cyto.2012.04.016
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE