View : 32 Download: 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author이은경-
dc.date.accessioned2017-08-28T23:04:47Z-
dc.date.available2017-08-28T23:04:47Z-
dc.date.issued2012-
dc.identifier.issn0140-7783-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/222811-
dc.description.abstractThis study aimed at assessing the predictive performance of a target-controlled infusion (TCI) system, which incorporates canine PK-PD models for microemulsion and long-chain triglyceride emulsion (LCT) propofol and at investigating time independency of propofol effect on the observed electroencephalographic approximate entropy (ApEn) in TCI. Using a crossover design with a 7-day washout period, 28 healthy beagle dogs were randomized to receive TCI of both formulations in a stepwise or constant manner. Plasma propofol concentrations and ApEn were measured at preset intervals. Pooled biases, inaccuracies, divergences, and wobbles in pharmacokinetic and pharmacodynamic predictions were 2.1% (95% CI: -0.8 to 4.9), 18.1% (15.6-20.5), 1.9%/h, 7.3% (5.4-9.3), and -0.5% (-2.6 to 1.6), 8.7% (7.3-10.1), 2.5%/h, 6.0% (4.1-7.2) for microemulsion propofol, and -9.3% (-11.6 to -6.9), 20.1% (18.2-22.0), 5.1%/h, 7.6% (6.1-9.1) and 5.6% (4.1-7.1), 8.0% (6.9-9.3), 4.7%/h, 4.1% (3.1-5.1) for LCT propofol. Observed ApEn values over time were statistically not different across all time points in a TCI with constant manner. Canine PK-PD model of microemulsion propofol showed good predictive performances. Propofol effect (ApEn) was time independent as long as time is allowed for equilibration. © 2011 Blackwell Publishing Ltd.-
dc.languageEnglish-
dc.titleExternal validation of pharmacokinetic and pharmacodynamic models of microemulsion and long-chain triglyceride emulsion propofol in beagle dogs-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume35-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage329-
dc.relation.lastpage341-
dc.relation.journaltitleJournal of Veterinary Pharmacology and Therapeutics-
dc.identifier.doi10.1111/j.1365-2885.2011.01321.x-
dc.identifier.wosidWOS:000306006100003-
dc.identifier.scopusid2-s2.0-84863553396-
dc.author.googleLee S.-H.-
dc.author.googlePark H.-W.-
dc.author.googleKim M.-J.-
dc.author.googleNoh M.-H.-
dc.author.googleYoon H.-S.-
dc.author.googleChoi B.-M.-
dc.author.googleLee E.-K.-
dc.author.googleNoh G.-J.-
dc.contributor.scopusid이은경(57188770360)-
dc.date.modifydate20170518153236-
Appears in Collections:
자연과학대학 > 통계학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE