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Resting cerebral glucose metabolism and perfusion patterns in women with posttraumatic stress disorder related to sexual assault

Title
Resting cerebral glucose metabolism and perfusion patterns in women with posttraumatic stress disorder related to sexual assault
Authors
Kim S.-Y.Chung Y.-K.Kim B.S.Lee S.J.Yoon J.-K.An Y.-S.
Ewha Authors
김범산
SCOPUS Author ID
김범산scopus
Issue Date
2012
Journal Title
Psychiatry Research - Neuroimaging
ISSN
0925-4927JCR Link
Citation
vol. 201, no. 3, pp. 214 - 217
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In the literature, numerous trials using neuroimaging techniques have investigated brain function in patients with post-traumatic stress disorder (PTSD). However, the contrasting results showed that improvements, including in the study design, were required to reach consistent and convincing conclusions. This study evaluated the functional neuroimaging pattern of resting cerebral blood flow and glucose metabolism in patients with PTSD related to sexual assault. Twelve patients were enrolled for both brain single photon emission computed tomography (SPECT) and 18F-fluorodeoxyglucose positron emission tomography (PET) investigations. All data were analyzed with statistical parametric mapping 2 (SPM2). The PTSD patients showed significant relative decreases in perfusion in the left hippocampus and in the basal ganglia compared with the control group. The PTSD group also had significantly lower cerebral glucosemetabolic activity in the left hippocampus and the superior temporal and precentral gyri than in the control group. These specific patterns of perfusion and glucose metabolism may be closely related to various neurophysiologic symptoms of PTSD. © 2012 Elsevier Ireland Ltd.
DOI
10.1016/j.pscychresns.2011.08.007
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의과대학 > 의학과 > Journal papers
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