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Cytomegalovirus infection in patients with new onset ulcerative colitis: A prospective study

Title
Cytomegalovirus infection in patients with new onset ulcerative colitis: A prospective study
Authors
Kim Y.S.Kim Y.-H.Kim J.S.Cheon J.H.Ye B.D.Jung S.-A.Park Y.S.Choi C.H.Jang B.I.Han D.S.Yang S.-K.Kim W.H.
Ewha Authors
정성애
SCOPUS Author ID
정성애scopus
Issue Date
2012
Journal Title
Hepato-Gastroenterology
ISSN
0172-6390JCR Link
Citation
vol. 59, no. 116, pp. 1098 - 1101
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background/Aims: Immunosuppressive therapy in ulcerative colitis (UC) may induce cytomegalovirus (CMV) infection or reactivation in the colonic mucosa and in turn exacerbate UC. However, it is unclear whether colonic inflammation itself affects CMV infection in UC. This prospective study evaluated the prevalence and clinical outcome of CMV infection in patients with new onset UC who have not been exposed to UC medication. Methodology: A prospective, multi-center study was conducted in 65 patients with new onset UC. The presence of CMV was evaluated by a serology test and a histopathological examination including immunohistochemical staining. The assessment of clinical outcome was performed based on CMV positivity. Results: Evidence of CMV infection was found in three (4.5%) patients with UC. Two patients with moderate disease activity improved with 5-aminosalicylate or steroid treatment. One patient with severe active colitis, however, required antiviral therapy. Conclusions: CMV infection is rare in new onset UC, which suggests that use of immunosuppressive medications is an important risk factor for CMV infection in UC. However, CMV evaluation is necessary for severe active UC, even with new onset of the disease. © H.G.E. Update Medical Publishing S.A., Athens.
DOI
10.5754/hge10217
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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