Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이지희 | * |
dc.contributor.author | 정영해 | * |
dc.contributor.author | 조민선 | * |
dc.contributor.author | 박은미 | * |
dc.date.accessioned | 2016-08-28T12:08:30Z | - |
dc.date.available | 2016-08-28T12:08:30Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 0741-5400 | * |
dc.identifier.other | OAK-8863 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222716 | - |
dc.description.abstract | Mer signaling participates in a novel inhibitory pathway in TLR activation. The purpose of the present study was to examine the role of Mer signaling in the down-regulation of TLR4 activation-driven immune responses in mice, i.t.-treated with LPS, using the specific Mer-blocking antibody. At 4 h and 24 h after LPS treatment, expression of Mer protein in alveolar macrophages and lung tissue decreased, sMer in BALF increased significantly, and Mer activation increased. Pretreatment with anti-Mer antibody did not influence the protein levels of Mer and sMer levels. Anti-Mer antibody significantly reduced LPS-induced Mer activation, phosphorylation of Akt and FAK, STAT1 activation, and expression of SOCS1 and -3. Anti-Mer antibody enhanced LPS-induced inflammatory responses, including activation of the NF-κB pathway; the production of TNF-α, IL-1β, and MIP-2 and MMP-9 activity; and accumulation of inflammatory cells and the total protein levels in BALF. These results indicate that Mer plays as an intrinsic feedback inhibitor of the TLR4- and inflammatory mediator-driven immune responses during acute lung injury. © Society for Leukocyte Biology. | * |
dc.language | English | * |
dc.title | Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-κB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 91 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 921 | * |
dc.relation.lastpage | 932 | * |
dc.relation.journaltitle | Journal of Leukocyte Biology | * |
dc.identifier.doi | 10.1189/jlb.0611289 | * |
dc.identifier.wosid | WOS:000304770200010 | * |
dc.identifier.scopusid | 2-s2.0-84861951340 | * |
dc.author.google | Lee Y.-J. | * |
dc.author.google | Han J.-Y. | * |
dc.author.google | Byun J. | * |
dc.author.google | Park H.-J. | * |
dc.author.google | Park E.-M. | * |
dc.author.google | Chong Y.H. | * |
dc.author.google | Cho M.-S. | * |
dc.author.google | Kang J.L. | * |
dc.contributor.scopusid | 이지희(7404517577) | * |
dc.contributor.scopusid | 정영해(7201371824) | * |
dc.contributor.scopusid | 조민선(13205279200) | * |
dc.contributor.scopusid | 박은미(35933416400) | * |
dc.date.modifydate | 20240123095000 | * |