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Is the association between ACE genes and blood pressure mediated by postnatal growth during the first 3 years?
- Is the association between ACE genes and blood pressure mediated by postnatal growth during the first 3 years?
- Min J.; Kim Y.J.; Lee H.; Park E.A.; Cho S.J.; Hong Y.M.; Oh S.-Y.; Ha E.; Kang D.; Park H.
- Ewha Authors
- 하은희; 홍영미; 강덕희; 박은애; 김영주; 박혜숙; 이화영; 조수진; 민정원
- SCOPUS Author ID
- 하은희; 홍영미; 강덕희; 박은애; 김영주; 박혜숙; 이화영; 조수진
- Issue Date
- Journal Title
- Early Human Development
- Early Human Development vol. 88, no. 6, pp. 425 - 429
- SCI; SCIE; SCOPUS
- Document Type
- Unlike the defined role of angiotensin-converting enzyme (ACE) gene in adult hypertension, ACE gene did not show direct influence on childhood blood pressure (BP), rather, seemed to be related to childhood growth with age-dependent characteristics. Thus, we examined intermediate effects of postnatal growth between the ACE polymorphisms and BP. We analyzed data from 257 children born in 2001-04 at Ewha Womans University Hospital in Seoul, Korea, and followed them up until 3. years of age. Children with excessive adiposity had higher BP, as rapid growers did to no-change and decelerated growers. The ACE II genotype was associated with greater growth acceleration than the DD genotype (II: 46.8% vs. DD: 23.9%), and with a higher BP. The interactions between ACE genotype and adiposity at age 3 were significant on the BP levels. The highest BP increase with the same degree of adiposity was observed in those with the II genotype [β (SE) for BMI: 1.9 (0.9), p= 0.04]; particularly, only rapid grown II carriers demonstrated statistical significance on this linear association. These results suggested that ACE polymorphisms and BP association are mediated by postnatal growth. Further studies are required to determine the age-specific ACE genetic effects and its undefined biological mechanism. © 2011 Elsevier Ltd.
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- 의과대학 > 의학과 > Journal papers
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