View : 51 Download: 0

Is the association between ACE genes and blood pressure mediated by postnatal growth during the first 3 years?

Title
Is the association between ACE genes and blood pressure mediated by postnatal growth during the first 3 years?
Authors
Min J.Kim Y.J.Lee H.Park E.A.Cho S.J.Hong Y.M.Oh S.-Y.Ha E.Kang D.Park H.
Ewha Authors
하은희홍영미강덕희박은애김영주박혜숙이화영조수진민정원
SCOPUS Author ID
하은희scopus; 홍영미scopus; 강덕희scopus; 박은애scopus; 김영주scopus; 박혜숙scopus; 이화영scopus; 조수진scopus
Issue Date
2012
Journal Title
Early Human Development
ISSN
0378-3782JCR Link
Citation
vol. 88, no. 6, pp. 425 - 429
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Unlike the defined role of angiotensin-converting enzyme (ACE) gene in adult hypertension, ACE gene did not show direct influence on childhood blood pressure (BP), rather, seemed to be related to childhood growth with age-dependent characteristics. Thus, we examined intermediate effects of postnatal growth between the ACE polymorphisms and BP. We analyzed data from 257 children born in 2001-04 at Ewha Womans University Hospital in Seoul, Korea, and followed them up until 3. years of age. Children with excessive adiposity had higher BP, as rapid growers did to no-change and decelerated growers. The ACE II genotype was associated with greater growth acceleration than the DD genotype (II: 46.8% vs. DD: 23.9%), and with a higher BP. The interactions between ACE genotype and adiposity at age 3 were significant on the BP levels. The highest BP increase with the same degree of adiposity was observed in those with the II genotype [β (SE) for BMI: 1.9 (0.9), p= 0.04]; particularly, only rapid grown II carriers demonstrated statistical significance on this linear association. These results suggested that ACE polymorphisms and BP association are mediated by postnatal growth. Further studies are required to determine the age-specific ACE genetic effects and its undefined biological mechanism. © 2011 Elsevier Ltd.
DOI
10.1016/j.earlhumdev.2011.10.008
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE