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Application of acid-catalyzed hydrolysis of dispersed organic solvent in developing new microencapsulation process technology

Title
Application of acid-catalyzed hydrolysis of dispersed organic solvent in developing new microencapsulation process technology
Authors
Lee H.Lee S.Bhattacharjee H.Sah H.
Ewha Authors
사홍기
SCOPUS Author ID
사홍기scopus
Issue Date
2012
Journal Title
Journal of Microencapsulation
ISSN
0265-2048JCR Link
Citation
vol. 29, no. 4, pp. 380 - 387
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The aim of this study was to evaluate a new microencapsulation technology employing an acid-catalyzed solvent extraction method in conjunction to an emulsion-based microencapsulation process. Its process consisted of emulsifying a dispersed phase of poly(D,L-lactide-co-glycolide) and isopropyl formate in an aqueous phase. This step was followed by adding hydrochloric acid to the resulting oil-in-water emulsion, in order to initiate the hydrolysis of isopropyl formate dissolved in the aqueous phase. Its hydrolysis caused the liberation of water-soluble species, that is, isopropanol and formic acid. This event triggered continual solvent leaching out of emulsion droplets, thereby initiating microsphere solidification. This new processing worked well for encapsulation of progesterone and ketoprofen that were chosen as a nonionizable model drug and a weakly acidic one, respectively. Furthermore, the structural integrity of poly(D,L-lactide-co-glycolide) was retained during microencapsulation. The new microencapsulation technology, being conceptually different from previous approaches, might be useful in preparing various polymeric particles. © 2012 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
DOI
10.3109/02652048.2011.651502
Appears in Collections:
약학대학 > 약학과 > Journal papers
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