Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이상기 | * |
dc.date.accessioned | 2016-08-28T12:08:21Z | - |
dc.date.available | 2016-08-28T12:08:21Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 0039-7881 | * |
dc.identifier.other | OAK-8766 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222630 | - |
dc.description.abstract | The palladium-catalyzed intramolecular N-arylation of the Blaise reaction intermediate, formed by reaction of nitriles with an in situ generated Reformatsky reagent from ethyl -bromo - (2-bromophenyl)acetate and zinc, afforded indoles in good yields. Extension of this approach to the chemoselective intramolecular N-alkylation/palladium-catalyzed N-arylation of the Blaise reaction intermediate, having -chloroalkyl appendages, provided a novel route for the tandem one-pot synthesis of N-fused indole derivatives. In contrast, the intermolecular coupling reaction of the Blaise reaction intermediates with 1,2-dihalobenzene did not proceed in the presence of a palladium catalyst, but proceeded in the presence of copper(I) iodide as the catalyst and resulted in indoles. 1 Introduction 2 Results and Discussion 2.1 Palladium-Catalyzed Intramolecular C-N Coupling Reaction of the Blaise Reaction Intermediate 2.2 Chemoselective Intramolecular N-Alkylation/Palladium-Catalyzed C-N Coupling Reaction of the Blaise Reaction Intermediate 2.3 Copper-Catalyzed Intermolecular N-C/C-C Coupling Reaction of the Blaise Reaction Intermediate with 1,2-Dihaloarenes 3 Conclusion. © 2012 Georg Thieme Verlag Stuttgart • New York. | * |
dc.language | English | * |
dc.title | Tandem one-pot construction of indoles via palladium and copper-catalyzed coupling reactions of the blaise reaction intermediate | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 44 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1464 | * |
dc.relation.lastpage | 1476 | * |
dc.relation.journaltitle | Synthesis | * |
dc.identifier.doi | 10.1055/s-0031-1289753 | * |
dc.identifier.wosid | WOS:000303775900003 | * |
dc.identifier.scopusid | 2-s2.0-84860747264 | * |
dc.author.google | Kim J.H. | * |
dc.author.google | Lee S.-G. | * |
dc.contributor.scopusid | 이상기(15082786300) | * |
dc.date.modifydate | 20240123104103 | * |