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Different temporal patterns in the expressions of bone morphogenetic proteins and noggin during astroglial scar formation after ischemic stroke

Title
Different temporal patterns in the expressions of bone morphogenetic proteins and noggin during astroglial scar formation after ischemic stroke
Authors
Shin J.A.Kang J.L.Lee K.-E.Park E.-M.
Ewha Authors
이지희이경은박은미
SCOPUS Author ID
이지희scopus; 이경은scopus; 박은미scopus
Issue Date
2012
Journal Title
Cellular and Molecular Neurobiology
ISSN
0272-4340JCR Link
Citation
vol. 32, no. 4, pp. 587 - 597
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Bone morphogenetic proteins (BMPs) and their antagonists have roles in scar formation and regeneration after central nervous system injuries. However, temporal changes in their expression during astroglial scar formation in the ischemic brain are unknown. Here, we examined protein levels of BMP2, BMP7, and their antagonist noggin in the ischemic brain up to 4 weeks after experimental stroke in mice. BMP2 and BMP7 levels were increased from 1 to 4 weeks in the ischemic brain, and their expression was associated with astrogliosis. BMP7 expression was more intense and co-localized in reactive astrocytes in the ischemic subcortex at 1 week. Noggin expression began to increase after 2 weeks and was further increased at 4 weeks only in the ischemic subcortex, but the intensity was weak compared to the intensity of BMPs. Noggin was co-localized mainly in activated microglia. These findings show that expression of BMPs and noggin differed over time, in intensity and in types of cell, and suggest that BMPs and noggin have different roles in the processes of glial scar formation and neurorestoration in the ischemic brain. © 2011 Springer Science+Business Media, LLC.
DOI
10.1007/s10571-012-9806-6
Appears in Collections:
의과대학 > 의학과 > Journal papers
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