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dc.contributor.author이상국-
dc.date.accessioned2016-08-28T12:08:18Z-
dc.date.available2016-08-28T12:08:18Z-
dc.date.issued2012-
dc.identifier.issn0278-6915-
dc.identifier.otherOAK-8724-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/222598-
dc.description.abstractMultidrug resistance (MDR) is a major obstacle in effective chemotherapy for cancer patients. The expression of P-glycoprotein (P-gp) in cancer cells is highly correlated with resistance to chemotherapeutic drugs. (-)-Antofine, a phenanthroindolizidine alkaloid derived from Cynanchum paniculatum, inhibits the growth of various human cancer cells. In this study, we further explored the potential of (-)-antofine to overcome the resistance induced by anti-cancer drugs. To this end, we established the paclitaxel-resistant human lung cancer cell line A549-PA by gradually exposing A549 cells to increasing concentrations of paclitaxel. As a result, the A549-PA cells acquired resistance against paclitaxel treatment and had an IC 50 that was more than 200 times that of the parental A549 cells. (-)-Antofine, however, effectively suppressed the growth of both the parental and drug-resistant cells. Additional studies revealed that the anti-proliferative activity of (-)-antofine in A549-PA cells is accompanied by a down-regulation of P-gp mRNA and protein expression. The effect of reversing the multidrug resistance of A549-PA cells via (-)-antofine treatment was demonstrated an increase in intracellular rhodamine-123 accumulation, measured using FACS analysis. These findings suggest an additional chemotherapeutic value of (-)-antofine, that is, regulation of cancer cell drug resistance, in addition to its antitumor effect. © 2011 Elsevier Ltd.-
dc.languageEnglish-
dc.titleAnti-proliferative activity and suppression of P-glycoprotein by (-)-antofine, a natural phenanthroindolizidine alkaloid, in paclitaxel-resistant human lung cancer cells-
dc.typeArticle-
dc.relation.issue41337-
dc.relation.volume50-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1060-
dc.relation.lastpage1065-
dc.relation.journaltitleFood and Chemical Toxicology-
dc.identifier.doi10.1016/j.fct.2011.11.008-
dc.identifier.wosidWOS:000303284600087-
dc.identifier.scopusid2-s2.0-84862796034-
dc.author.googleKim E.-H.-
dc.author.googleMin H.-Y.-
dc.author.googleChung H.-J.-
dc.author.googleSong J.-
dc.author.googlePark H.-J.-
dc.author.googleKim S.-
dc.author.googleLee S.K.-
dc.contributor.scopusid이상국(36067620500)-
dc.date.modifydate20211210153309-
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약학대학 > 약학과 > Journal papers
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