Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이상국 | - |
dc.date.accessioned | 2016-08-28T12:08:18Z | - |
dc.date.available | 2016-08-28T12:08:18Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.other | OAK-8724 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222598 | - |
dc.description.abstract | Multidrug resistance (MDR) is a major obstacle in effective chemotherapy for cancer patients. The expression of P-glycoprotein (P-gp) in cancer cells is highly correlated with resistance to chemotherapeutic drugs. (-)-Antofine, a phenanthroindolizidine alkaloid derived from Cynanchum paniculatum, inhibits the growth of various human cancer cells. In this study, we further explored the potential of (-)-antofine to overcome the resistance induced by anti-cancer drugs. To this end, we established the paclitaxel-resistant human lung cancer cell line A549-PA by gradually exposing A549 cells to increasing concentrations of paclitaxel. As a result, the A549-PA cells acquired resistance against paclitaxel treatment and had an IC 50 that was more than 200 times that of the parental A549 cells. (-)-Antofine, however, effectively suppressed the growth of both the parental and drug-resistant cells. Additional studies revealed that the anti-proliferative activity of (-)-antofine in A549-PA cells is accompanied by a down-regulation of P-gp mRNA and protein expression. The effect of reversing the multidrug resistance of A549-PA cells via (-)-antofine treatment was demonstrated an increase in intracellular rhodamine-123 accumulation, measured using FACS analysis. These findings suggest an additional chemotherapeutic value of (-)-antofine, that is, regulation of cancer cell drug resistance, in addition to its antitumor effect. © 2011 Elsevier Ltd. | - |
dc.language | English | - |
dc.title | Anti-proliferative activity and suppression of P-glycoprotein by (-)-antofine, a natural phenanthroindolizidine alkaloid, in paclitaxel-resistant human lung cancer cells | - |
dc.type | Article | - |
dc.relation.issue | 41337 | - |
dc.relation.volume | 50 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1060 | - |
dc.relation.lastpage | 1065 | - |
dc.relation.journaltitle | Food and Chemical Toxicology | - |
dc.identifier.doi | 10.1016/j.fct.2011.11.008 | - |
dc.identifier.wosid | WOS:000303284600087 | - |
dc.identifier.scopusid | 2-s2.0-84862796034 | - |
dc.author.google | Kim E.-H. | - |
dc.author.google | Min H.-Y. | - |
dc.author.google | Chung H.-J. | - |
dc.author.google | Song J. | - |
dc.author.google | Park H.-J. | - |
dc.author.google | Kim S. | - |
dc.author.google | Lee S.K. | - |
dc.contributor.scopusid | 이상국(36067620500) | - |
dc.date.modifydate | 20211210153309 | - |