Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 조영주 | * |
dc.date.accessioned | 2016-08-28T12:08:18Z | - |
dc.date.available | 2016-08-28T12:08:18Z | - |
dc.date.issued | 2012 | * |
dc.identifier.issn | 2092-7355 | * |
dc.identifier.other | OAK-8720 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222595 | - |
dc.description.abstract | Purpose: Aspirin and non-steroidal anti-inflammatory drugs (ASA/NSAIDs) are common causes of drug hypersensitivity. An oral provocation test is the only definitive diagnostic test. This study assessed the reliability of a flow cytometry-assisted basophil activation test (FAST) as a safe diagnostic method for ASA/NSAID-induced hypersensitivity, as its high sensitivity and specificity have been demonstrated for many other drugs. Methods: Eighteen patients and 11 controls were enrolled. Using a Flow-CAST kit® (Bühlmann Laboratories AG, Schönenbuch, Switzerland), 29 analyses with aspirin, ibuprofen, and diclofenac were performed by flow cytometry to detect double-positive staining of anti-IgE and anti-CD63. The stimulation index was defined as the activated basophil percentage after drug stimulation/basally active basophil percentage. A stimulation index≥2 and an absolute activated basophil percentage≥5 were considered positive. Results: Patients with hypersensitivity to ASA/NSAIDs were predominantly female, and the prevalence of atopy was higher in patients than in controls. A sensitivity of 61%, specificity of 91%, positive predictive value of 92%, and negative predictive value of 59% were achieved. Conclusions: FAST is a useful additional method for diagnosis of hypersensitivity reactions to ASA/NSAIDs. Further development is required to increase the sensitivity of the test. © The Korean Academy of Asthma, Allergy and Clinical Immunology. | * |
dc.language | English | * |
dc.title | Flow cytometry-assisted basophil activation test as a safe diagnostic tool for aspirin/NSAID hypersenstivity | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 4 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 137 | * |
dc.relation.lastpage | 142 | * |
dc.relation.journaltitle | Allergy, Asthma and Immunology Research | * |
dc.identifier.doi | 10.4168/aair.2012.4.3.137 | * |
dc.identifier.wosid | WOS:000303226200005 | * |
dc.identifier.scopusid | 2-s2.0-84861762725 | * |
dc.author.google | Kim M.S. | * |
dc.author.google | Cho Y.J. | * |
dc.contributor.scopusid | 조영주(55472202600;56657140200) | * |
dc.date.modifydate | 20240118125203 | * |