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A theoretical study of nonlinear capacitance of mammalian out hair cell by a nontransporting five-state model

Title
A theoretical study of nonlinear capacitance of mammalian out hair cell by a nontransporting five-state model
Authors
Zhang L.Zhang Y.Kim C.K.Lee K.-J.-B.
Ewha Authors
이공주복
SCOPUS Author ID
이공주복scopus
Issue Date
2012
Journal Title
Modern Physics Letters B
ISSN
0217-9849JCR Link
Citation
vol. 26, no. 13
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Understanding the nonlinear capacitance (NLC) of prestin and outer hair cell (OHC) is important for exploring the activity of mammalian cochlea. After introducing a nontransporting five-state model of the OHC motor which is the tetramer of prestin, we obtain the peak of the NLC of OHC and the peak shift of the NLC as functions of the concentration of the intracellular Cl - anions. By employing the same model, we calculate the frequency dependence of the NLC as well. The model results both in equilibrium state and of the frequency dependence agree with the experimental observations. Accordingly, it suggests that the introduced five-state model is a candidate for exploring the NLC of both OHC and prestin. © 2012 World Scientific Publishing Company.
DOI
10.1142/S0217984912500807
Appears in Collections:
자연과학대학 > 물리학전공 > Journal papers
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