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Assessment of risk factors for Korean children with Kawasaki disease

Title
Assessment of risk factors for Korean children with Kawasaki disease
Authors
Kim J.-J.Hong Y.M.Yun S.W.Han M.K.Lee K.-Y.Song M.S.Lee H.-D.Kim D.S.Sohn S.Ha K.-S.Hong S.-J.Kim K.-J.Park I.-S.Jang G.Y.Lee J.-K.
Ewha Authors
홍영미손세정
SCOPUS Author ID
홍영미scopus; 손세정scopus
Issue Date
2012
Journal Title
Pediatric Cardiology
ISSN
0172-0643JCR Link
Citation
vol. 33, no. 4, pp. 513 - 520
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Kawasaki disease (KD) is the most common cause of acquired heart disease in children. Intravenous immunoglobulin (IVIG) is the standard therapy for KD, but more than 10% ofKDpatients do not respond to IVIG and are at high risk for the development of coronary artery lesions (CALs). To identify clinical and genetic risk factors associated with CAL development and IVIG nonresponsiveness, this study analyzed the clinical data for 478 Korean KD patients. Multivariate logistic regression analysis showed that incomplete KD, IVIG nonresponse, fever duration of 7 days or longer, and the CC/ACgenotypes of the rs7604693 single nucleotide polymorphism (SNP) in the PELI1 gene were significantly associated with the development of CALs, with odds ratios (ORs) ranging from 2.06 to 3.04. The risk of CAL formation was synergistically increased by the addition of individual risk factors, particularly the genetic variant in the PELI1 gene. Multivariate analysis also showed that a serum albumin level of 3.6 g/dl or lower was significantly associated with nonresponsiveness to IVIG [OR, 2.76; 95% confidence interval (CI), 1.34-5.68; P = 0.006]. Conclusively, incomplete KD, IVIG nonresponsiveness, long febrile days, and the rs7604693 genetic variant in the PELI1 gene are major risk factors for the development of CALs, whereas low serumalbumin concentration is an independent risk factor for IVIG nonresponsiveness. © Springer Science+Business Media, LLC 2011.
DOI
10.1007/s00246-011-0143-1
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의학전문대학원 > 의학과 > Journal papers
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